Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.
lifelong football training
mitochondrial oxidative capacity
polyamines
successful aging
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
28 11 2022
28 11 2022
Historique:
received:
31
10
2022
revised:
21
11
2022
accepted:
23
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.
Sections du résumé
BACKGROUND
Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.
METHODS
The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on
RESULTS
Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.
CONCLUSIONS
Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.
Identifiants
pubmed: 36497910
pii: ijerph192315835
doi: 10.3390/ijerph192315835
pmc: PMC9740844
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11140-5
pubmed: 9736703
Elife. 2022 Apr 11;11:
pubmed: 35404238
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Metabolites. 2021 Mar 09;11(3):
pubmed: 33803435
Mol Cell Biochem. 2004 Jul;262(1-2):127-33
pubmed: 15532717
J Cell Physiol. 2011 Jun;226(6):1453-60
pubmed: 21413019
Int J Mol Sci. 2018 Nov 13;19(11):
pubmed: 30428564
J Sports Sci. 2018 Jul;36(14):1630-1639
pubmed: 29160161
Transgenic Res. 2013 Jun;22(3):595-605
pubmed: 23080295
Am J Clin Nutr. 2020 May 1;111(5):975-982
pubmed: 32246717
Mol Nutr Food Res. 2008 Jul;52(7):780-8
pubmed: 18626887
Best Pract Res Clin Rheumatol. 2017 Apr;31(2):203-217
pubmed: 29224697
Sci Rep. 2018 Feb 19;8(1):3308
pubmed: 29459697
Nat Rev Genet. 2012 Jul 10;13(8):589-94
pubmed: 22777128
Exerc Sport Sci Rev. 2010 Jul;38(3):105-13
pubmed: 20577058
Diabetes. 2008 Nov;57(11):2933-42
pubmed: 18716044
Front Physiol. 2019 Mar 26;10:312
pubmed: 30971946
Biochem Biophys Res Commun. 2003 Feb 21;301(4):915-22
pubmed: 12589799
Int J Mol Sci. 2022 Jan 28;23(3):
pubmed: 35163441
J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):66-73
pubmed: 21546582
Ageing Res Rev. 2017 Sep;38:6-17
pubmed: 28648951
EMBO Rep. 2013 Dec;14(12):1113-9
pubmed: 24136413
Mol Cell Probes. 2015 Feb;29(1):43-7
pubmed: 25444938
Sci Rep. 2015 Dec 21;5:18450
pubmed: 26688341
Int J Mol Sci. 2022 Jul 06;23(14):
pubmed: 35886840
Am J Physiol Cell Physiol. 2022 May 1;322(5):C913-C926
pubmed: 35353634
Eur J Appl Physiol. 2017 Apr;117(4):721-730
pubmed: 28251397
Front Public Health. 2022 Aug 22;10:975608
pubmed: 36072381
Br J Sports Med. 2018 Nov;52(22):1412-1414
pubmed: 29886433
BMC Biol. 2018 Aug 20;16(1):93
pubmed: 30124168
Front Physiol. 2019 Feb 19;10:132
pubmed: 30837897
Sports Med Open. 2019 Aug 22;5(1):38
pubmed: 31440862
Aging Cell. 2021 Apr;20(4):e13325
pubmed: 33730416
Br J Surg. 2016 Jan;103(2):e29-46
pubmed: 26771470
Physiol Rev. 2019 Jan 1;99(1):427-511
pubmed: 30427277
Nanoscale. 2021 Mar 18;13(10):5251-5269
pubmed: 33666624
Scand J Med Sci Sports. 2015 Feb;25(1):61-9
pubmed: 24303918
Diabetes Metab Syndr. 2021 Mar-Apr;15(2):589-594
pubmed: 33714133
Eur Rev Aging Phys Act. 2022 Apr 29;19(1):13
pubmed: 35488197
Eur J Appl Physiol. 2021 Oct;121(10):2903-2912
pubmed: 34212217
Int J Mol Sci. 2020 Jun 12;21(12):
pubmed: 32545699
Int J Environ Res Public Health. 2020 Mar 21;17(6):
pubmed: 32245237
Anticancer Res. 2005 Mar-Apr;25(2A):965-9
pubmed: 15868935
Br J Sports Med. 2015 May;49(9):568-76
pubmed: 25878072
Scand J Med Sci Sports. 2010 Apr;20 Suppl 1:80-9
pubmed: 20210904
J Mol Biol. 2015 Oct 23;427(21):3389-406
pubmed: 26156863
Scand J Med Sci Sports. 2010 Apr;20 Suppl 1:1-13
pubmed: 20210908
Br J Sports Med. 2020 Dec;54(24):1451-1462
pubmed: 33239350
Biochem Biophys Res Commun. 2017 Apr 22;486(1):83-87
pubmed: 28263745
Cell Metab. 2017 Mar 7;25(3):581-592
pubmed: 28273480
Eur J Clin Invest. 2000 Jan;30(1):72-8
pubmed: 10620005
OMICS. 2011 Nov;15(11):775-81
pubmed: 22011340
J Am Geriatr Soc. 2014 Feb;62(2):230-6
pubmed: 24438020
J Proteomics. 2015 Jun 03;122:119-32
pubmed: 25857276
Am J Prev Med. 2007 Dec;33(6):502-4
pubmed: 18022068
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552
pubmed: 34723319
Med Sci (Basel). 2018 Feb 14;6(1):
pubmed: 29443878
Mol Genet Metab. 2021 Jun;133(2):157-181
pubmed: 33965309
J Biol Chem. 2007 Jun 29;282(26):18793-9
pubmed: 17488713
Biochemistry (Mosc). 2003 Aug;68(8):850-6
pubmed: 12948384
J Zhejiang Univ Sci B. 2012 Apr;13(4):283-97
pubmed: 22467370
Br J Sports Med. 2015 Nov;49(22):1426-7
pubmed: 25990758