Fetal Bradycardia Caused by Monogenic Disorders-A Review of the Literature.
arrhythmia
bradycardia
fetal
genetics
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
22 Nov 2022
22 Nov 2022
Historique:
received:
14
10
2022
revised:
03
11
2022
accepted:
18
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
12
12
2022
Statut:
epublish
Résumé
Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken into consideration in case of diagnosed fetal bradycardia. Methods: A literature review was conducted using a PubMed- and OMIM-based search for monogenetic disorders causing fetal bradycardia in September 2022. Results: The review on the literature identified nine monogenic diseases that could lead to fetal bradycardia. Four of these disorders can be associated with extracardiac findings. Discussion: Genetic testing should be considered in cases with fetal bradycardia, especially in cases of additional extracardiac findings. Broad sequencing techniques and improved prenatal phenotyping could help to establish a diagnosis in an increasing number of cases.
Identifiants
pubmed: 36498454
pii: jcm11236880
doi: 10.3390/jcm11236880
pmc: PMC9741304
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Front Genet. 2022 Feb 24;13:821226
pubmed: 35281812
Ultrasound Obstet Gynecol. 2000 Dec;16(7):610-3
pubmed: 11169365
Nat Commun. 2018 Oct 3;9(1):4065
pubmed: 30283131
J Am Coll Cardiol. 2014 Aug 26;64(8):745-56
pubmed: 25145517
Front Pediatr. 2021 May 17;9:668546
pubmed: 34079780
Am J Cardiol. 2004 Mar 15;93(6):788-91
pubmed: 15019897
Pediatr Cardiol. 1999 Jul-Aug;20(4):304-7
pubmed: 10368461
Nat Rev Cardiol. 2010 May;7(5):277-90
pubmed: 20418904
J Med Genet. 1996 Jan;33(1):47-51
pubmed: 8825048
Prenat Diagn. 1999 Jun;19(6):575-9
pubmed: 10416977
Am J Perinatol. 2014 Aug;31(7):617-28
pubmed: 24858320
J Am Coll Cardiol. 2014 Aug 26;64(8):757-67
pubmed: 25145518
Am J Obstet Gynecol. 1981 Feb 1;139(3):299-305
pubmed: 7468698
Circ Arrhythm Electrophysiol. 2020 May;13(5):e008082
pubmed: 32421437
Cardiovasc Res. 2004 Nov 1;64(2):268-78
pubmed: 15485686
Am Heart J. 1957 Jul;54(1):59-68
pubmed: 13435203
Circulation. 2013 Nov 12;128(20):2183-91
pubmed: 24218437
Circulation. 2014 May 27;129(21):2183-242
pubmed: 24763516
Clin Res Cardiol. 2011 Dec;100(12):1123-7
pubmed: 21915623
Heart Rhythm. 2013 May;10(5):728-37
pubmed: 23291057
Biol Sex Differ. 2018 Apr 18;9(1):16
pubmed: 29669590
Circulation. 2012 Dec 4;126(23):2688-95
pubmed: 23124029
Circ Genom Precis Med. 2020 Aug;13(4):e002775
pubmed: 32527150
Genet Med. 2015 May;17(5):405-24
pubmed: 25741868
Circulation. 2020 Jul 28;142(4):324-338
pubmed: 32429735
Prenat Diagn. 2005 Aug;25(8):704-8
pubmed: 16052576
Neoreviews. 2016 Oct;17(10):e568-e578
pubmed: 28042286
Mol Genet Metab. 2017 Jan - Feb;120(1-2):96-100
pubmed: 27692944
Am J Med Genet A. 2017 Mar;173(3):784-789
pubmed: 28211989
Pacing Clin Electrophysiol. 2020 Apr;43(4):430-433
pubmed: 32168391
HeartRhythm Case Rep. 2020 Mar 20;6(6):352-356
pubmed: 32577394
HeartRhythm Case Rep. 2016 Sep 21;3(1):53-57
pubmed: 28491768
J Am Coll Cardiol. 2004 Mar 3;43(5):826-30
pubmed: 14998624
Mol Syndromol. 2011 Sep;1(6):307-310
pubmed: 22190901
Obstet Gynecol. 2010 Nov;116(5):1232-40
pubmed: 20966730
Am J Hum Genet. 2020 Jan 2;106(1):102-111
pubmed: 31883641