Enzymatically Modified Isoquercitrin: Production, Metabolism, Bioavailability, Toxicity, Pharmacology, and Related Molecular Mechanisms.
ADME
AGIQ
absorption
anti-inflammatory
cardioprotective
chemopreventive
flavonols
isoquercitrin oligoglucosides
musculotropic
neuroprotective
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Nov 2022
26 Nov 2022
Historique:
received:
31
10
2022
revised:
20
11
2022
accepted:
23
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Quercetin and its glycosides, such as isoquercitrin or rutin, are among the most ubiquitous flavonoids present in plants. They possess numerous health-promoting properties, whose applicability is, however, limited by poor water solubility and absorption issues. Enzymatically modified isoquercitrin (EMIQ) is an isoquercitrin derivative obtained from rutin via enzymatic transformations that greatly enhance its bioavailability. Due to advantageous reports on its safety and bioactivity, EMIQ is currently gaining importance as a food additive and a constituent of dietary supplements. This review summarizes the thus-far-conducted investigations into the metabolism, toxicity, biological properties, and molecular mechanisms of EMIQ and presents a comprehensive characterization of this valuable substance, which might represent the future of flavonoid supplementation.
Identifiants
pubmed: 36499113
pii: ijms232314784
doi: 10.3390/ijms232314784
pmc: PMC9738368
pii:
doi:
Substances chimiques
Quercetin
9IKM0I5T1E
Rutin
5G06TVY3R7
Glycosides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical University of Lodz
ID : 503/3-022-01/503-31-001
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