Microbiota Composition in Diverticular Disease: Implications for Therapy.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Nov 2022
Historique:
received: 27 10 2022
revised: 21 11 2022
accepted: 23 11 2022
entrez: 11 12 2022
pubmed: 12 12 2022
medline: 15 12 2022
Statut: epublish

Résumé

Gut microbiota (GM) composition and its imbalance are crucial in the pathogenesis of several diseases, mainly those affecting the gastrointestinal tract. Colon diverticulosis and its clinical manifestations (diverticular disease, DD) are among the most common digestive disorders in developed countries. In recent literature, the role of GM imbalance in the onset of the different manifestations within the clinical spectrum of DD has been highlighted. This narrative review aims to summarize and critically analyze the current knowledge on GM dysbiosis in diverticulosis and DD by comparing the available data with those found in inflammatory bowel disease (IBD). The rationale for using probiotics to rebalance dysbiosis in DD is also discussed.

Identifiants

pubmed: 36499127
pii: ijms232314799
doi: 10.3390/ijms232314799
pmc: PMC9736941
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Antonio Tursi (A)

Territorial Gastroenterology Service, ASL BAT, 70031 Andria, Italy.
Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy.

Valerio Papa (V)

Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy.
Digestive Surgery, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy.

Loris Riccardo Lopetuso (LR)

Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy.
Department of Medicine and Ageing Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.

Carlo Romano Settanni (CR)

Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy.

Antonio Gasbarrini (A)

Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy.
Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy.

Alfredo Papa (A)

Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy.
Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy.

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