TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 Dec 2022
Historique:
received: 01 11 2022
revised: 01 12 2022
accepted: 05 12 2022
entrez: 11 12 2022
pubmed: 12 12 2022
medline: 15 12 2022
Statut: epublish

Résumé

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (

Identifiants

pubmed: 36499693
pii: ijms232315366
doi: 10.3390/ijms232315366
pmc: PMC9737899
pii:
doi:

Substances chimiques

Receptor, trkA EC 2.7.10.1
Nerve Growth Factors 0
Receptor, trkC EC 2.7.10.1
Oncogene Proteins, Fusion 0
Biomarkers, Tumor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Veneto Institute of Oncology (IOV)-I.R.C.C.S
ID : project 5x1000, section Sinergia, title PROSOFT

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Auteurs

Rocco Cappellesso (R)

Pathological Anatomy Unit, Padua University Hospital, 35121 Padua, Italy.

Lorenzo Nicolè (L)

Department of Pathology, Angelo Hospital, 30174 Venice, Italy.
Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.

Paolo Del Fiore (P)

Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Luisa Barzon (L)

Department of Molecular Medicine (DMM), University of Padua, 35121 Padua, Italy.

Alessandro Sinigaglia (A)

Department of Molecular Medicine (DMM), University of Padua, 35121 Padua, Italy.

Silvia Riccetti (S)

Department of Molecular Medicine (DMM), University of Padua, 35121 Padua, Italy.

Renato Franco (R)

Pathology Unit, University of Campania "L. Vanvitelli", 80129 Naples, Italy.

Federica Zito Marino (F)

Pathology Unit, University of Campania "L. Vanvitelli", 80129 Naples, Italy.

Giada Munari (G)

Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Carolina Zamuner (C)

Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Francesco Cavallin (F)

Independent Statistician, 36020 Solagna, Italy.

Marta Sbaraglia (M)

Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.

Francesca Galuppini (F)

Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.

Franco Bassetto (F)

Department of Neurosciences (DNS), University of Padua, 35128 Padua, Italy.

Mauro Alaibac (M)

Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.

Vanna Chiarion-Sileni (V)

Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Luisa Piccin (L)

Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Clara Benna (C)

Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy.

Matteo Fassan (M)

Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Simone Mocellin (S)

Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy.

Angelo Paolo Dei Tos (AP)

Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.

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Classifications MeSH