Myotoxin-3 from the Pacific Rattlesnake
anti-microtubule agent
crotamine
snake venom
tubulin
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Nov 2022
25 Nov 2022
Historique:
received:
21
10
2022
revised:
19
11
2022
accepted:
19
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Microtubule targeting agents (MTA) are anti-cancer molecules that bind tubulin and interfere with the microtubule functions, eventually leading to cell death. In the present study, we used an in vitro microtubule polymerization assay to screen several venom families for the presence of anti-microtubule activity. We isolated myotoxin-3, a peptide of the crotamine family, and three isoforms from the venom of the Northern Pacific rattlesnake
Identifiants
pubmed: 36500334
pii: molecules27238241
doi: 10.3390/molecules27238241
pmc: PMC9739105
pii:
doi:
Substances chimiques
Neurotoxins
0
Tubulin
0
Crotalid Venoms
0
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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