ACE-Vitamin Index and Risk of Glaucoma: The SUN Project.
SUN project
glaucoma
vitamin A
vitamin C
vitamin E
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
02 Dec 2022
02 Dec 2022
Historique:
received:
02
11
2022
revised:
24
11
2022
accepted:
30
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants' dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios. A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55-0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (≥55 year). The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma.
Sections du résumé
BACKGROUND
BACKGROUND
Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project.
METHODS
METHODS
For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants' dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios.
RESULTS
RESULTS
A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55-0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (≥55 year).
CONCLUSIONS
CONCLUSIONS
The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma.
Identifiants
pubmed: 36501162
pii: nu14235129
doi: 10.3390/nu14235129
pmc: PMC9735492
pii:
doi:
Substances chimiques
Vitamins
0
Ascorbic Acid
PQ6CK8PD0R
Vitamin E
1406-18-4
Antioxidants
0
Vitamin A
11103-57-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Government-Instituto de Salud Carlos III, the European Regional Development Fund (FEDER)
ID : RD 06/0045, CIBER-OBN, Grant PI20/00564
Organisme : National Plan on Drugs
ID : 2020/021
Références
Optom Vis Sci. 2008 Jun;85(6):406-16
pubmed: 18521010
Zhongguo Yao Li Xue Bao. 1999 Oct;20(10):879-83
pubmed: 11270984
J Glaucoma. 2007 May;16(3):334-43
pubmed: 17438430
JAMA Ophthalmol. 2016 Mar;134(3):294-303
pubmed: 26767881
Sci Rep. 2016 May 11;6:25792
pubmed: 27165400
J Glaucoma. 2008 Jun-Jul;17(4):263-8
pubmed: 18552610
Public Health Nutr. 2010 Sep;13(9):1364-72
pubmed: 20105389
Eur J Epidemiol. 2012 May;27(5):385-93
pubmed: 22461101
J Nutr. 2000 Mar;130(3):503-6
pubmed: 10702576
JAMA. 2013 May 15;309(19):2005-15
pubmed: 23644932
J Optom. 2017 Apr - Jun;10(2):71-78
pubmed: 27025415
Eur J Pharmacol. 2016 Sep 15;787:119-26
pubmed: 27089818
Arch Ophthalmol. 2005 Apr;123(4):458-63
pubmed: 15824217
Nutrients. 2018 Mar 16;10(3):
pubmed: 29547516
Antioxidants (Basel). 2022 Sep 09;11(9):
pubmed: 36139859
Am J Clin Nutr. 1997 Jul;66(1):116-22
pubmed: 9209178
Clin Nutr ESPEN. 2021 Feb;41:110-117
pubmed: 33487252
Eye (Lond). 2013 Apr;27(4):487-94
pubmed: 23429409
J Trace Elem Med Biol. 2021 Sep;67:126789
pubmed: 34044222
Curr Eye Res. 2014 Aug;39(8):823-9
pubmed: 24912005
Nutrients. 2022 Oct 01;14(19):
pubmed: 36235733
Clin Nutr. 2014 Dec;33(6):1041-5
pubmed: 24290344
Int J Ophthalmol. 2012;5(2):231-7
pubmed: 22762057
Eur J Ophthalmol. 2021 Apr 25;:11206721211012862
pubmed: 33896221
Int J Mol Sci. 2022 Jan 18;23(3):
pubmed: 35162940
Mutat Res. 2006 Mar;612(2):105-14
pubmed: 16413223
Annu Rev Nutr. 2021 Oct 11;41:105-131
pubmed: 34115520
Am J Med. 2003 Jun 1;114(8):638-46
pubmed: 12798451
Am J Ophthalmol. 2012 Oct;154(4):635-44
pubmed: 22818906
Arch Ophthalmol. 2001 Oct;119(10):1417-36
pubmed: 11594942
Nutrients. 2022 Feb 12;14(4):
pubmed: 35215429
Nutrients. 2018 Mar 31;10(4):
pubmed: 29614726
World J Virol. 2022 Sep 25;11(5):300-309
pubmed: 36188745
Ophthalmology. 2014 Nov;121(11):2081-90
pubmed: 24974815
Am J Epidemiol. 2003 Aug 15;158(4):337-46
pubmed: 12915499
Adv Food Nutr Res. 2018;83:281-310
pubmed: 29477224
Free Radic Biol Med. 2021 Dec;177:100-119
pubmed: 34695546
Cureus. 2020 Nov 24;12(11):e11686
pubmed: 33391921
Graefes Arch Clin Exp Ophthalmol. 2010 Feb;248(2):243-8
pubmed: 19763599