Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1.
Cell migration
corticosteroids
fibroblasts
scratch
assay
triamcinolone
Journal
Clinical hemorheology and microcirculation
ISSN: 1875-8622
Titre abrégé: Clin Hemorheol Microcirc
Pays: Netherlands
ID NLM: 9709206
Informations de publication
Date de publication:
05 Dec 2022
05 Dec 2022
Historique:
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
12
12
2022
Statut:
aheadofprint
Résumé
Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects. The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients. An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone. There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone. The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
Sections du résumé
BACKGROUND
BACKGROUND
Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects.
OBJECTIVE
OBJECTIVE
The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients.
METHODS
METHODS
An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone.
RESULTS
RESULTS
There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone.
CONCLUSIONS
CONCLUSIONS
The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
Identifiants
pubmed: 36502314
pii: CH229106
doi: 10.3233/CH-229106
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM