The effect of home-based transcranial direct current stimulation in cognitive performance in fibromyalgia: A randomized, double-blind sham-controlled trial.
cognition
fibromyalgia
pain
tDCS
working memory
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
07
2022
accepted:
22
09
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
13
12
2022
Statut:
epublish
Résumé
Transcranial Direct Current Stimulation (tDCS) is a promising approach to improving fibromyalgia (FM) symptoms, including cognitive impairment. So, we evaluated the efficacy and safety of home-based tDCS in treating cognitive impairment. Besides, we explored if the severity of dysfunction of the Descendant Pain Modulation System (DPMS) predicts the tDCS effect and if its effect is linked to changes in neuroplasticity as measured by the brain-derived neurotrophic factor (BDNF). This randomized, double-blind, parallel, sham-controlled clinical trial, single-center, included 36 women with FM, aged from 30 to 65 years old, assigned 2:1 to receive a-tDCS ( GLM showed a main effect for treatment in the TMT-B-A [Wald χ2 = 6.176; Df = 1; These findings revealed that daily treatment with a home-based tDCS device over l-DLPFC compared to sham stimulation over 4 weeks improved the cognitive impairment in FM. The a-tDCS at home was well-tolerated, underlining its potential as an alternative treatment for cognitive dysfunction. Besides, the a-tDCS effect is related to the severity of DPMS dysfunction and changes in neuroplasticity state. [www.ClinicalTrials.gov], identifier [NCT03843203].
Sections du résumé
Background
UNASSIGNED
Transcranial Direct Current Stimulation (tDCS) is a promising approach to improving fibromyalgia (FM) symptoms, including cognitive impairment. So, we evaluated the efficacy and safety of home-based tDCS in treating cognitive impairment. Besides, we explored if the severity of dysfunction of the Descendant Pain Modulation System (DPMS) predicts the tDCS effect and if its effect is linked to changes in neuroplasticity as measured by the brain-derived neurotrophic factor (BDNF).
Methods
UNASSIGNED
This randomized, double-blind, parallel, sham-controlled clinical trial, single-center, included 36 women with FM, aged from 30 to 65 years old, assigned 2:1 to receive a-tDCS (
Results
UNASSIGNED
GLM showed a main effect for treatment in the TMT-B-A [Wald χ2 = 6.176; Df = 1;
Conclusion
UNASSIGNED
These findings revealed that daily treatment with a home-based tDCS device over l-DLPFC compared to sham stimulation over 4 weeks improved the cognitive impairment in FM. The a-tDCS at home was well-tolerated, underlining its potential as an alternative treatment for cognitive dysfunction. Besides, the a-tDCS effect is related to the severity of DPMS dysfunction and changes in neuroplasticity state.
Clinical trial registration
UNASSIGNED
[www.ClinicalTrials.gov], identifier [NCT03843203].
Identifiants
pubmed: 36504629
doi: 10.3389/fnhum.2022.992742
pmc: PMC9730884
doi:
Banques de données
ClinicalTrials.gov
['NCT03843203']
Types de publication
Journal Article
Langues
eng
Pagination
992742Informations de copyright
Copyright © 2022 Serrano, Zortea, Alves, Beltrán, Bavaresco, Ramalho, Alves, Medeiros, Sanches, Silva, Lucena da Silva Torres, Fregni and Caumo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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