Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [
angiotensin-converting enzyme I (ACE I)
cardiovascular diseases (CVDs)
natural drugs
renin-angiotensin-aldosterone system (RAAS)
soy products
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
10
2022
accepted:
03
11
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
13
12
2022
Statut:
epublish
Résumé
Angiotensin-converting enzyme I (ACE I) is a zinc-containing metallopeptidase involved in the renin-angiotensin system (RAAS) that helps in the regulation of hypertension and maintains fluid balance otherwise, which results in cardiovascular diseases (CVDs). One of the leading reasons of global deaths is due to CVDs. RAAS also plays a central role in maintaining homeostasis of the CV system. The commercial drugs available to treat CVDs possess several fatal side effects. Hence, phytochemicals like peptides having plant-based origin should be explored and utilized as alternative therapies. Soybean is an important leguminous crop that simultaneously possesses medicinal properties. Soybean extracts are used in many drug formulations for treating diabetes and other disorders and ailments. Soy proteins and its edible products such as tofu have shown potential inhibitory activity against ACE. Thus, this review briefly describes various soy proteins and products that can be used to inhibit ACE thereby providing new scope for the identification of potential candidates that can help in the design of safer and natural treatments for CVDs.
Identifiants
pubmed: 36505231
doi: 10.3389/fnut.2022.1068388
pmc: PMC9730416
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1068388Informations de copyright
Copyright © 2022 Ramlal, Nautiyal, Baweja, Kumar, Mehta, Mahto, Tripathi, Shanmugam, Pujari Mallikarjuna, Raman, Lal, Raju and Rajendran.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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