Multi-omics approach to identifying isoform variants as therapeutic targets in cancer patients.
alternative splicing
biomarker
proteomics
therapeutic discovery
transcriptomics
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
09
2022
accepted:
07
11
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
13
12
2022
Statut:
epublish
Résumé
Cancer-specific alternatively spliced events (ASE) play a role in cancer pathogenesis and can be targeted by immunotherapy, oligonucleotide therapy, and small molecule inhibition. However, identifying actionable ASE targets remains challenging due to the uncertainty of its protein product, structure impact, and proteoform (protein isoform) function. Here we argue that an integrated multi-omics profiling strategy can overcome these challenges, allowing us to mine this untapped source of targets for therapeutic development. In this review, we will provide an overview of current multi-omics strategies in characterizing ASEs by utilizing the transcriptome, proteome, and state-of-art algorithms for protein structure prediction. We will discuss limitations and knowledge gaps associated with each technology and informatics analytics. Finally, we will discuss future directions that will enable the full integration of multi-omics data for ASE target discovery.
Identifiants
pubmed: 36505834
doi: 10.3389/fonc.2022.1051487
pmc: PMC9730332
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1051487Informations de copyright
Copyright © 2022 Shaw, Zhao, Li, Wang, Wang, Manley, Stewart and Karolak.
Déclaration de conflit d'intérêts
TS reports a patent for EBD CAR US20220267425A1. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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