Sex differences in epigenetic age in Mediterranean high longevity regions.
DNA methylation
biological age
biomarker
blue zone
centenarian
epigenetic clock
telomere
Journal
Frontiers in aging
ISSN: 2673-6217
Titre abrégé: Front Aging
Pays: Switzerland
ID NLM: 9918231199706676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
07
2022
accepted:
21
10
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
13
12
2022
Statut:
epublish
Résumé
Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to men. However, in the Mediterranean Blue Zones of Sardinia (Italy) and Ikaria (Greece) are regions of centenarian abundance, male-female centenarian ratios are approximately one, diverging from the typical trend and making these useful regions in which to study sex differences of the oldest old. Additionally, these regions can be investigated as examples of healthy aging relative to other populations. DNA methylation (DNAm)-based predictors have been developed to assess various health biomarkers, including biological age, Pace of Aging, serum interleukin-6 (IL-6), and telomere length. Epigenetic clocks are biological age predictors whose deviation from chronological age has been indicative of relative health differences between individuals, making these useful tools for interrogating these differences in aging. We assessed sex differences between the Horvath, Hannum, GrimAge, PhenoAge, Skin and Blood, and Pace of Aging predictors from individuals in two Mediterranean Blue Zones and found that men displayed positive epigenetic age acceleration (EAA) compared to women according to all clocks, with significantly greater rates according to GrimAge (β = 3.55;
Identifiants
pubmed: 36506464
doi: 10.3389/fragi.2022.1007098
pii: 1007098
pmc: PMC9726738
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1007098Informations de copyright
Copyright © 2022 Engelbrecht, Merrill, Gladish, MacIsaac, Lin, Ecker, Chrysohoou, Pes, Kobor and Rehkopf.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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