Comparison of Pharmacokinetics of the GalNAc-Conjugated Antisense Oligonucleotide GSK3389404 in Participants with Chronic Hepatitis B Infection across the Asia-Pacific Region.
Asia-Pacific
GSK3389404
antisense oligonucleotide
chronic hepatitis B virus infection
pharmacokinetics
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
24 01 2023
24 01 2023
Historique:
pubmed:
13
12
2022
medline:
27
1
2023
entrez:
12
12
2022
Statut:
ppublish
Résumé
GSK3389404, an N-acetyl galactosamine-conjugated antisense oligonucleotide (ASO), was in clinical development for chronic hepatitis B (CHB) treatment. Few studies have examined ASOs in Asian participants. In this analysis, the plasma pharmacokinetics (PK) of GSK3389404 were characterized and compared in patients with CHB across the Asia-Pacific region (N = 64), including mainland China (
Identifiants
pubmed: 36507675
doi: 10.1128/aac.00900-22
pmc: PMC9872700
doi:
Substances chimiques
Oligonucleotides, Antisense
0
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0090022Références
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