Case report: radiation-induced lumbosacral plexopathy - a very late complication of radiotherapy for cervical cancer.
Case report
Cervical cancer
Lumbosacral plexus
Radiation-induced lumbosacral plexopathy
Radiotherapy
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
12 Dec 2022
12 Dec 2022
Historique:
received:
15
08
2022
accepted:
02
12
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Lumbosacral plexopathy caused by radiotherapy is a rare but severe consequence of cancer treatment. This condition often leads to varying degrees of sensory and motor impairment. Neurological complications, which are typically permanent, manifest a long period after irradiation. We describe a case of progressive lower extremity weakness and sensory impairment in a woman who had been effectively treated with radiotherapy for cervical cancer with development 36 years after irradiation. The electrophysiological assessment revealed a subacute bilateral axonal lesion of the lumbosacral plexus. None of the clinical manifestations, serology, cerebrospinal fluid or imaging data discovered an explanation other than radiation-induced lumbosacral plexopathy (RILP). This case demonstrates that RILP may emerge more than 30 years after the radiotherapy.
Sections du résumé
BACKGROUND
BACKGROUND
Lumbosacral plexopathy caused by radiotherapy is a rare but severe consequence of cancer treatment. This condition often leads to varying degrees of sensory and motor impairment. Neurological complications, which are typically permanent, manifest a long period after irradiation.
CASE PRESENTATION
METHODS
We describe a case of progressive lower extremity weakness and sensory impairment in a woman who had been effectively treated with radiotherapy for cervical cancer with development 36 years after irradiation. The electrophysiological assessment revealed a subacute bilateral axonal lesion of the lumbosacral plexus. None of the clinical manifestations, serology, cerebrospinal fluid or imaging data discovered an explanation other than radiation-induced lumbosacral plexopathy (RILP).
CONCLUSIONS
CONCLUSIONS
This case demonstrates that RILP may emerge more than 30 years after the radiotherapy.
Identifiants
pubmed: 36510189
doi: 10.1186/s12883-022-03013-5
pii: 10.1186/s12883-022-03013-5
pmc: PMC9743098
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
475Subventions
Organisme : Masarykova Univerzita
ID : MUNI/A/1144/2021
Organisme : Masarykova Univerzita
ID : MUNI/IGA/1162/2021
Informations de copyright
© 2022. The Author(s).
Références
No To Shinkei. 1990 Jul;42(7):629-33
pubmed: 2171605
Cancer. 1990 Oct 1;66(7):1488-92
pubmed: 2169990
Arch Neurol. 1984 Dec;41(12):1282-5
pubmed: 6093750
J Clin Oncol. 2019 Jan 10;37(2):135-143
pubmed: 30457920
Neurology. 1985 Jan;35(1):1-7
pubmed: 2981416
Rev Neurol. 2000 Jan 1-15;30(1):97
pubmed: 10743005
Lancet Neurol. 2015 Feb;14(2):162-73
pubmed: 25575710
Medicine (Baltimore). 2015 May;94(17):e766
pubmed: 25929915
Cancer Treat Rev. 2003 Oct;29(5):389-99
pubmed: 12972357
Semin Radiat Oncol. 2007 Apr;17(2):99-107
pubmed: 17395040
Diagnostics (Basel). 2021 Jan 05;11(1):
pubmed: 33466426
Radiother Oncol. 2012 Dec;105(3):273-82
pubmed: 23245644
Clin Neurophysiol Pract. 2020 Aug 13;5:173-193
pubmed: 32954064
Can J Neurol Sci. 1977 Nov;4(4):259-63
pubmed: 597799
Int J Radiat Oncol Biol Phys. 1993 Jun 15;26(3):479-82
pubmed: 8514543
Rev Neurol (Paris). 2020 May;176(5):325-352
pubmed: 32276788
Contemp Oncol (Pozn). 2012;16(2):194-6
pubmed: 23788877
Cases J. 2009 Sep 15;2:6838
pubmed: 19918550
Gynecol Oncol Res Pract. 2015 Dec 04;2:12
pubmed: 27231572