Magnetic Resonance Elastography as Surrogate Marker of Interstitial Fibrosis in Kidney Transplantation: A Prospective Study.
elastography
fibrosis
histopathology
kidney transplantation
magnetic resonance imaging
prospective studies
transplantation
Journal
Kidney360
ISSN: 2641-7650
Titre abrégé: Kidney360
Pays: United States
ID NLM: 101766381
Informations de publication
Date de publication:
24 11 2022
24 11 2022
Historique:
received:
22
06
2022
accepted:
29
08
2022
entrez:
14
12
2022
pubmed:
15
12
2022
medline:
16
12
2022
Statut:
epublish
Résumé
Fibrosis progression is a major prognosis factor in kidney transplantation. Its assessment requires an allograft biopsy, which remains an invasive procedure at risk of complications. We assessed renal stiffness by magnetic resonance elastography (MRE) as a surrogate marker of fibrosis in a prospective cohort of kidney transplant recipients compared with the histologic gold standard. Interstitial fibrosis was evaluated by three methods: the semi-quantitative Banff ci score, a visual quantitative evaluation by a pathologist, and a computer-assisted quantitative evaluation. MRE-derived stiffness was assessed at the superior, median, and inferior poles of the allograft. We initially enrolled 73 patients, but only 55 had measurements of their allograft stiffness by MRE before an allograft biopsy. There was no significant correlation between MRE-derived stiffness at the biopsy site and the ci score ( MRE-derived stiffness does not directly reflect the extent of fibrosis in kidney transplantation.
Sections du résumé
Background
Fibrosis progression is a major prognosis factor in kidney transplantation. Its assessment requires an allograft biopsy, which remains an invasive procedure at risk of complications.
Methods
We assessed renal stiffness by magnetic resonance elastography (MRE) as a surrogate marker of fibrosis in a prospective cohort of kidney transplant recipients compared with the histologic gold standard. Interstitial fibrosis was evaluated by three methods: the semi-quantitative Banff ci score, a visual quantitative evaluation by a pathologist, and a computer-assisted quantitative evaluation. MRE-derived stiffness was assessed at the superior, median, and inferior poles of the allograft.
Results
We initially enrolled 73 patients, but only 55 had measurements of their allograft stiffness by MRE before an allograft biopsy. There was no significant correlation between MRE-derived stiffness at the biopsy site and the ci score (
Conclusions
MRE-derived stiffness does not directly reflect the extent of fibrosis in kidney transplantation.
Identifiants
pubmed: 36514413
doi: 10.34067/KID.0004282022
pii: 02200512-202211000-00015
pmc: PMC9717636
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1924-1933Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 by the American Society of Nephrology.
Déclaration de conflit d'intérêts
L. Couzi reports consultancy for Astellas, Biotest, Hansa, Novartis, and Otsuka; and honoraria from Astellas, Biotest; Hansa, and Otsuka. P. Merville reports consultancy for Astellas and BMS; research funding from Astellas; honoraria from CSL Behring and Sanofi; and an advisory or leadership role for BMS and Novartis. J. Visentin reports being the inventor on a patent concerning a method to quantify anti-HLA antibodies in patient samples using surface plasmon resonance (WO 2017/168083). All remaining authors have nothing to disclose.
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