A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8.
ROS scavenging
autophagy
cardiac overexpression of human ADCY8
cell biology
left ventricle
mouse
nutrient sensing
proliferation
protection from apoptosis
protein synthesis
proteome
proteosome 35 activity
transcriptome
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 12 2022
14 12 2022
Historique:
received:
10
06
2022
accepted:
08
12
2022
pubmed:
15
12
2022
medline:
11
1
2023
entrez:
14
12
2022
Statut:
epublish
Résumé
Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TG
Identifiants
pubmed: 36515265
doi: 10.7554/eLife.80949
pii: 80949
pmc: PMC9822292
doi:
pii:
Substances chimiques
adenylyl cyclase 8
EC 4.6.1.1
Banques de données
GEO
['GSE205234']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL155218
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL061912
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115560
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136918
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063030
Pays : United States
Déclaration de conflit d'intérêts
KT, KC, DR, AL, IA, MP, AS, JZ, MW, YL, JQ, MB, MJ, YT, BZ, RT, VK, MR, JL, RB, Rd, SJ, GK, AG, DY, MA, LA, CM, WO, CC, SC, NP, TH, KP, RW, LF, SS, EL No competing interests declared
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