Hypoxia induces transgenerational epigenetic inheritance of small RNAs.

Animals Caenorhabditis elegans / genetics Inheritance Patterns Caenorhabditis elegans Proteins / genetics RNA, Small Interfering / genetics RNA, Double-Stranded / genetics Epigenesis, Genetic Hypoxia / genetics RNA Interference
C. elegans CP: Molecular biology F44E5.4/5 HRDE-1 germ granule hypoxia small RNA transgenerational epigenetic inheritance

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
13 12 2022
Historique:
received: 04 03 2022
revised: 23 09 2022
accepted: 17 11 2022
entrez: 14 12 2022
pubmed: 15 12 2022
medline: 17 12 2022
Statut: ppublish

Résumé

Animals sense and adapt to decreased oxygen availability, but whether and how hypoxia exposure in ancestors can elicit phenotypic consequences in normoxia-reared descendants are unclear. We show that hypoxia educes an intergenerational reduction in lipids and a transgenerational reduction in fertility in the nematode Caenorhabditis elegans. The transmission of these epigenetic phenotypes is dependent on repressive histone-modifying enzymes and the argonaute HRDE-1. Feeding naive C. elegans small RNAs extracted from hypoxia-treated worms is sufficient to induce a fertility defect. Furthermore, the endogenous small interfering RNA F44E5.4/5 is upregulated intergenerationally in response to hypoxia, and soaking naive normoxia-reared C. elegans with F44E5.4/5 double-stranded RNA (dsRNA) is sufficient to induce an intergenerational fertility defect. Finally, we demonstrate that labeled F44E5.4/5 dsRNA is itself transmitted from parents to children. Our results suggest that small RNAs respond to the environment and are sufficient to transmit non-genetic information from parents to their naive children.

Identifiants

DOI: 10.1016/j.celrep.2022.111800 PMID: 36516753 PMC: PMC9847139
pubmed: 36516753
pii: S2211-1247(22)01688-6
doi: 10.1016/j.celrep.2022.111800
pmc: PMC9847139
mid: NIHMS1857908
pii:
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
RNA, Small Interfering 0
RNA, Double-Stranded 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

111800

Subventions

Organisme : NIA NIH HHS
ID : DP2 AG055947
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG043550
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007466
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Simon Yuan Wang (SY)

Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: yuan.wang@childrens.harvard.edu.

Kathleen Kim (K)

Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Zach Klapholz O'Brown (ZK)

Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Aileen Levan (A)

Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Anne Elizabeth Dodson (AE)

Department of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA 02115, USA.

Scott G Kennedy (SG)

Department of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA 02115, USA.

Chaim Chernoff (C)

Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Eric Lieberman Greer (EL)

Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: eric.greer@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ARN double brin › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hypoxia induces transgenerational epigenetic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Hypoxia induces transgenerational epigenetic...