Time-restricted eating did not alter insulin sensitivity or β-cell function in adults with obesity: A randomized pilot study.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
27
09
2022
received:
01
06
2022
accepted:
29
09
2022
pubmed:
16
12
2022
medline:
27
1
2023
entrez:
15
12
2022
Statut:
ppublish
Résumé
Decreased insulin sensitivity and impairment of β-cell function predate and predict development of type 2 diabetes mellitus. Time-restricted eating (TRE) might have a benefit for these parameters. The objective of this pilot study was to investigate this possibility. Secondary analysis of a randomized controlled trial comparing 12 weeks of TRE (8-hour eating window) to unrestricted eating (non-TRE) was performed. Participants were adults with overweight or obesity and without diabetes. Two-hour oral glucose tolerance testing was performed at baseline and end-intervention. Glucose tolerance test-derived measures of insulin sensitivity, insulin secretion, and β-cell function were compared between groups. Participants (17 women/3 men with mean [SD] age 45.5 [12.1] years and BMI 34.1 [7.5] kg/m In adults with overweight or obesity and without diabetes, TRE did not significantly alter insulin sensitivity, insulin secretion, or β-cell function over a 12-week intervention. Whether TRE is beneficial in adults with prediabetes or type 2 diabetes mellitus warrants further investigation.
Identifiants
pubmed: 36518093
doi: 10.1002/oby.23620
pmc: PMC9877119
mid: NIHMS1842719
doi:
Substances chimiques
Insulin
0
Blood Glucose
0
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108-115Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK124484
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118278
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG065569
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK115906
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002494
Pays : United States
Informations de copyright
© 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
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