Case Report: Long-term observations from the tacrolimus weaning randomized clinical trial depicts the challenging aspects for determination of low-immunological risk patients.
allograft rejection
calcineurin inhibitor withdrawal
case report
donor specific antibodies
kidney transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
08
2022
accepted:
31
10
2022
entrez:
15
12
2022
pubmed:
16
12
2022
medline:
17
12
2022
Statut:
epublish
Résumé
Whilst calcineurin inhibitors (CNI) are the cornerstone of immunosuppressive maintenance therapy in kidney transplantation, several studies have investigated the safety of CNI withdrawal in order to avoid their numerous side effects. In this context, we performed several years ago a clinical randomized trial evaluating CNI weaning in stable kidney transplant recipients without anti-HLA immunization. The trial was interrupted prematurely due to a high number of
Identifiants
pubmed: 36518770
doi: 10.3389/fimmu.2022.1021481
pmc: PMC9744190
doi:
Substances chimiques
Tacrolimus
WM0HAQ4WNM
Calcineurin Inhibitors
0
Banques de données
ClinicalTrials.gov
['NCT01292525']
Types de publication
Randomized Controlled Trial
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1021481Investigateurs
Gilles Blancho
(G)
Julien Branchereau
(J)
Diego Cantarovich
(D)
Anne Cesbron
(A)
Agn Amp Xe S Chapelet
(AAXS)
Jacques Dantal
(J)
Anne Devis
(A)
Florent Delbos
(F)
Cl Amp Xe Ment Deltombe
(CAXM)
Lucile Figueres
(L)
Raphael Gaisne
(R)
Claire Garandeau
(C)
Magali Giral
(M)
Caroline Gourraud-Vercel
(C)
Maryvonne Hourmant
(M)
Christine Kandel-Aznar
(C)
Georges Karam
(G)
Clarisse Kerleau
(C)
Delphine Kervella
(D)
Claire Leman
(C)
Alice Leclech
(A)
Christophe Masset
(C)
Aur Amp Xe Lie Meurette
(AAXL)
Karine Renaudin
(K)
Simon Ville
(S)
Alexandre Walencik
(A)
Informations de copyright
Copyright © 2022 Masset, Dantal, Soulillou, Walencik, Delbos, Brouard, Giral and the Nantes DIVAT Consortium.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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