Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
15 12 2022
15 12 2022
Historique:
entrez:
15
12
2022
pubmed:
16
12
2022
medline:
17
12
2022
Statut:
epublish
Résumé
Opioid-induced hyperalgesia (OIH) is a state of paradoxically enhanced pain transmission, termed nociceptive sensitization, described to occur in both humans and animals after repeated administration of opioid drugs, including rapidly acting remifentanil. However, molecular mechanisms of OIH remain understudied. In this issue of the JCI, Yan Jin and colleagues provided strong evidence that hyperexcitable thalamocortical networks drive remifentanil-induced hyperalgesia in a rodent model of postsurgical pain. Furthermore, the authors specifically identified an important role of the CaV3.1 isoform of low-voltage-activated or T-type calcium channels (T-channels) in this process. Further experiments are needed to determine whether thalamic T channels could serve as targets for the treatment of OIH.
Identifiants
pubmed: 36519545
pii: 165977
doi: 10.1172/JCI165977
pmc: PMC9753988
doi:
pii:
Substances chimiques
Analgesics, Opioid
0
Calcium Channels, T-Type
0
Remifentanil
P10582JYYK
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM141802
Pays : United States
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