Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection.

Animals Mice Humans Hepatitis B, Chronic / drug therapy Capsid Hepatitis B virus Antiviral Agents / pharmacology Capsid Proteins / genetics RNA DNA, Viral / genetics DNA, Circular Hepatitis B / drug therapy

capsid assembly modulator hepatitis B virus

Journal

Antimicrobial agents and chemotherapy

ISSN: 1098-6596

Titre abrégé: Antimicrob Agents Chemother

Pays: United States

ID NLM: 0315061

Informations de publication

Date de publication:
24 01 2023

Historique:

pubmed: 16 12 2022

medline: 27 1 2023

entrez: 15 12 2022

Statut: ppublish

Résumé

The standard of care for the treatment of chronic hepatitis B (CHB) is typically lifelong treatment with nucleos(t)ide analogs (NAs), which suppress viral replication and provide long-term clinical benefits. However, infectious virus can still be detected in patients who are virally suppressed on NA therapy, which may contribute to the failure of these agents to cure most CHB patients. Accordingly, new antiviral treatment options are being developed to enhance the suppression of hepatitis B virus (HBV) replication in combination with NAs ("antiviral intensification"). Here, we describe GS-SBA-1, a capsid assembly modulator (CAM) belonging to class CAM-E, that demonstrates potent inhibition of extracellular HBV DNA

Identifiants

DOI: 10.1128/aac.01348-22 PMID: 36519892 PMC: PMC9872672

pubmed: 36519892

doi: 10.1128/aac.01348-22

pmc: PMC9872672

doi:

Substances chimiques

Antiviral Agents 0

Capsid Proteins 0

RNA 63231-63-0

DNA, Viral 0

DNA, Circular 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e0134822

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