Fetal development of functional thalamocortical and cortico-cortical connectivity.
fetal brain development
functional connectivity
magnetic resonance imaging
thalamus
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
24
04
2022
revised:
22
08
2022
accepted:
23
08
2022
medline:
3
5
2023
pubmed:
16
12
2022
entrez:
15
12
2022
Statut:
ppublish
Résumé
Measuring and understanding functional fetal brain development in utero is critical for the study of the developmental foundations of our cognitive abilities, possible early detection of disorders, and their prevention. Thalamocortical connections are an intricate component of shaping the cortical layout, but so far, only ex-vivo studies provide evidence of how axons enter the sub-plate and cortex during this highly dynamic phase. Evidence for normal in-utero development of the functional thalamocortical connectome in humans is missing. Here, we modeled fetal functional thalamocortical connectome development using in-utero functional magnetic resonance imaging in fetuses observed from 19th to 40th weeks of gestation (GW). We observed a peak increase of thalamocortical functional connectivity strength between 29th and 31st GW, right before axons establish synapses in the cortex. The cortico-cortical connectivity increases in a similar time window, and exhibits significant functional laterality in temporal-superior, -medial, and -inferior areas. Homologous regions exhibit overall similar mirrored connectivity profiles, but this similarity decreases during gestation giving way to a more diverse cortical interconnectedness. Our results complement the understanding of structural development of the human connectome and may serve as the basis for the investigation of disease and deviations from a normal developmental trajectory of connectivity development.
Identifiants
pubmed: 36520481
pii: 6908756
doi: 10.1093/cercor/bhac446
pmc: PMC10152101
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5613-5624Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015902
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB032708
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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