HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of Monocytes.

Humans Cytokines HIV Infections / metabolism Killer Cells, Natural / metabolism Monocytes CD56 Antigen Intestinal Mucosa / metabolism
HIV NK cell dysfunction TGF-β immune activation microbial translocation monocytes‌

Journal

The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675

Informations de publication

Date de publication:
14 02 2023
Historique:
received: 15 07 2022
accepted: 14 12 2022
pubmed: 16 12 2022
medline: 17 2 2023
entrez: 15 12 2022
Statut: ppublish

Résumé

The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-γ production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-β production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction.

Identifiants

DOI: 10.1093/infdis/jiac485 PMID: 36520641
pubmed: 36520641
pii: 6911135
doi: 10.1093/infdis/jiac485
doi:

Substances chimiques

Cytokines 0
CD56 Antigen 0
lipopolysaccharide-binding protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

577-582

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Déclaration de conflit d'intérêts

Potential conflicts of interest . G. J. R. has received travel expenses and honoraria from Gilead. C. B. has received honoraria for consulting or speaking at educational events from AbbVie, Gilead, Janssen, MSD, and ViiV. J. O. has received research funding from Bayer, Biotest, CSL Behring, Octapharma, Pfizer, Swedish Orphan Biovitrum, and Takeda; consultancy, speakers bureau, honoraria, scientific advisory board, and travel expenses from Bayer, Biogen Idec, BioMarin, Biotest, Chugai Pharmaceutical Co, Ltd, CSL Behring, Freeline, Grifols, Novo Nordisk, Octapharma, Pfizer, F. Hoffmann-La Roche Ltd, Sanofi, Spark Therapeutics, Swedish Orphan Biovitrum, and Takeda. J. K. R. has received honoraria for consulting or speaking at educational events from Abivax, Gilead, Janssen, Merck, Theratechnologies, and ViiV. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Auteurs

Michael ToVinh (M)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
ORCID: 0000-0002-1625-9741

Gregor Hörr (G)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Christoph Hoffmeister (C)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Kristiyana Dobrikova (K)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Christina Gotter (C)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Jan Raabe (J)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Kim M Kaiser (KM)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Sarah Ahmad (S)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Claudia Finnemann (C)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Eyleen Matejec (E)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Gudrun Hack (G)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Jenny Bischoff (J)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
ORCID: 0000-0002-7700-2915

Gereon J Rieke (GJ)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Carolynne Schwarze-Zander (C)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Christoph Boesecke (C)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Kathrin van Bremen (K)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Jan-Christian Wasmuth (JC)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Anna M Eis-Hübinger (AM)

Institute of Virology, University Hospital, University of Bonn, Bonn, Germany.

Hendrik Streeck (H)

Institute of Virology, University Hospital, University of Bonn, Bonn, Germany.

Hedda L Verhasselt (HL)

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Johannes Oldenburg (J)

Institute for Experimental Hematology and Transfusion Medicine, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Christian P Strassburg (CP)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Jürgen K Rockstroh (JK)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Ulrich Spengler (U)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

Benjamin Krämer (B)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Jacob Nattermann (J)

Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › HIV-Associated Microbial Translocation May...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › HIV-Associated Microbial Translocation May...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › HIV-Associated Microbial Translocation May...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › HIV-Associated Microbial Translocation May...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › HIV-Associated Microbial Translocation May...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD56 › HIV-Associated Microbial Translocation May...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › HIV-Associated Microbial Translocation May...