Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update.

Humans Quality of Life Migraine Disorders / complications Stroke / complications Migraine with Aura / complications Foramen Ovale, Patent / complications Ischemic Stroke / complications Epilepsy / complications

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
11 04 2023
Historique:
received: 13 06 2022
accepted: 01 11 2022
medline: 12 4 2023
pubmed: 16 12 2022
entrez: 15 12 2022
Statut: ppublish

Résumé

Migraine and stroke are highly prevalent diseases with a high effect on quality of life, with multiple epidemiologic, pathophysiologic, clinical, and prognostic areas of overlap. Migraine is a risk factor for stroke. This risk is explained by common risk factors, migraine-specific mechanisms, and non-migraine-specific mechanisms that have a relevant role in patients with migraine with aura (e.g., atrial fibrillation and paradoxical embolism through a patent foramen ovale). Another important link between migraine aura and ischemic stroke is cardiac embolism. Cardioembolism is the most frequent cause of ischemic stroke, and increasing evidence suggests that microembolism, predominantly but not exclusively originating in the heart, is a contributing mechanism to the development of migraine aura. In this review, we discuss epidemiologic aspects of the association between migraine and ischemic stroke, the clinical presentation of ischemic strokes in patients with migraine, and the differentiation between migrainous and nonmigrainous infarctions. After that, we review migraine-specific and non-migraine-specific stroke mechanisms. We then review updated preclinical and clinical data on microembolism as a cause of migraine aura. In the last section, we summarize knowledge gaps and important areas to explore in future research. The review includes a clinical vignette with a discussion of the most relevant topics addressed.

Identifiants

DOI: 10.1212/WNL.0000000000201699 PMID: 36522158 PMC: PMC10103117
pubmed: 36522158
pii: WNL.0000000000201699
doi: 10.1212/WNL.0000000000201699
pmc: PMC10103117
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

716-726

Subventions

Organisme : NINDS NIH HHS
ID : K08 NS124991
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

© 2022 American Academy of Neurology.

Références

Neurology. 2006 Oct 10;67(7):1128-34
pubmed: 17030745
Neurol Genet. 2022 Feb 01;8(1):e653
pubmed: 35128049
Stroke. 2018 Mar;49(3):573-578
pubmed: 29459398
Neurol Sci. 2017 Jan;38(1):33-40
pubmed: 27785579
Brain Res. 2018 Jan 15;1679:84-90
pubmed: 29183666
Stroke. 2015 Jan;46(1):229-36
pubmed: 25424478
Ann Neurol. 2011 Feb;69(2):413-8
pubmed: 21387384
Neurology. 2018 Dec 11;91(24):1077-1078
pubmed: 30429280
Stroke. 2007 Sep;38(9):2438-45
pubmed: 17690308
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
Neurology. 1977 Sep;27(9):843-8
pubmed: 561334
Neurology. 2012 Apr 17;78(16):1221-8
pubmed: 22491867
Eur J Neurol. 2021 Feb;28(2):516-524
pubmed: 32979886
Thromb Res. 2015 Jul;136(1):52-60
pubmed: 25936231
J Pain Res. 2019 Oct 21;12:2941-2950
pubmed: 31695483
Cephalalgia. 2015 Feb;35(2):95-117
pubmed: 25281220
Eur J Neurol. 2020 Dec;27(12):e97
pubmed: 32888332
Curr Neurol Neurosci Rep. 2010 May;10(3):167-73
pubmed: 20425031
Cephalalgia. 1989 Dec;9(4):255-8
pubmed: 2611882
Ann Neurol. 2021 Feb;89(2):242-253
pubmed: 33078475
Headache. 2007 Nov-Dec;47(10):1455-6
pubmed: 18052957
Ann Neurol. 2020 Oct;88(4):771-784
pubmed: 32583883
Neurology. 2020 Jan 7;94(1):e75-e86
pubmed: 31694924
Cephalalgia. 2015 Feb;35(2):165-81
pubmed: 25228681
Brain. 1987 Aug;110 ( Pt 4):917-34
pubmed: 3651801
Expert Rev Neurother. 2020 Apr;20(4):313-317
pubmed: 32056462
Neurology. 2011 May 31;76(22):1911-7
pubmed: 21624990
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92
pubmed: 11287655
J Am Heart Assoc. 2012 Dec;1(6):e001735
pubmed: 23316313
Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4856-61
pubmed: 18347334
BMJ. 2018 Jan 31;360:k96
pubmed: 29386181
Cephalalgia. 2015 Feb;35(2):88-94
pubmed: 24715500
Brain. 1984 Jun;107 ( Pt 2):447-61
pubmed: 6609739
Headache. 2010 Sep;50(8):1320-7
pubmed: 20132338
Stroke. 2018 May;49(5):1123-1128
pubmed: 29636424
Neurology. 2016 Dec 13;87(24):2527-2532
pubmed: 27956563
Exp Biol Med (Maywood). 2007 Feb;232(2):204-13
pubmed: 17259327
Ann Neurol. 2010 Feb;67(2):221-9
pubmed: 20225282
Am J Obstet Gynecol. 2017 May;216(5):489.e1-489.e7
pubmed: 28034652
Neurology. 2018 Dec 11;91(24):e2202-e2210
pubmed: 30429278
Circulation. 1998 Jul 7;98(1):25-30
pubmed: 9665056
Clin Neurol Neurosurg. 2018 Feb;165:7-9
pubmed: 29287235
J Cardiol. 2016 Jun;67(6):493-503
pubmed: 26527111
Cephalalgia. 2011 Jun;31(8):886-96
pubmed: 21511950
Stroke. 1994 May;25(5):974-9
pubmed: 8165693
J Headache Pain. 2017 Oct 30;18(1):108
pubmed: 29086160
J Cereb Blood Flow Metab. 2017 May;37(5):1571-1594
pubmed: 27328690
Cephalalgia. 2015 Feb;35(2):146-64
pubmed: 25505017
JAMA Neurol. 2017 May 1;74(5):512-518
pubmed: 28264095
Cephalalgia. 2021 Mar;41(3):375-382
pubmed: 33200948
Cephalalgia. 2004 Aug;24(8):623-30
pubmed: 15265050
Neurology. 2002 Sep 24;59(6):816-24
pubmed: 12297560
Circulation. 2012 Jan 17;125(2):335-45
pubmed: 22144569
Physiol Rev. 2015 Jul;95(3):953-93
pubmed: 26133935
Lancet Neurol. 2018 Nov;17(11):954-976
pubmed: 30353868
Neurology. 2015 May 26;84(21):2132-45
pubmed: 25934857
Cephalalgia. 2016 May;36(6):561-7
pubmed: 26419790
Eur J Neurol. 2011 Mar;18(3):504-11
pubmed: 20825470
Neurology. 2016 Dec 13;87(24):2504-2505
pubmed: 27956562
Physiol Rev. 2001 Jul;81(3):1065-96
pubmed: 11427692

Auteurs

Simona Sacco (S)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
ORCID: 0000-0003-0651-1939

Andrea M Harriott (AM)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.

Cenk Ayata (C)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.

Raffaele Ornello (R)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
ORCID: 0000-0001-9501-4031

Rodrigo Bagur (R)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
ORCID: 0000-0003-1888-9429

Amado Jimenez-Ruiz (A)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
ORCID: 0000-0002-0257-3107

Luciano A Sposato (LA)

From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada. lucianosposato@gmail.com.
ORCID: 0000-0001-6425-9343

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Migraine avec aura › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Malformations des cloisons cardiaques › Communications interauriculaires › Foramen ovale perméable › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Microembolism and Other Links Between Migraine...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Microembolism and Other Links Between Migraine...