Metabolic syndrome among treatment-naïve people living with and without HIV in Zambia and Zimbabwe: a cross-sectional analysis.
Africa
HIV epidemiology
metabolic syndrome
public health
risk factors
women
Journal
Journal of the International AIDS Society
ISSN: 1758-2652
Titre abrégé: J Int AIDS Soc
Pays: Switzerland
ID NLM: 101478566
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
30
04
2022
accepted:
18
11
2022
entrez:
15
12
2022
pubmed:
16
12
2022
medline:
20
12
2022
Statut:
ppublish
Résumé
Chronic viral replication has been linked to an increased risk of cardiovascular and metabolic diseases in people living with HIV (PLWH), but few studies have evaluated this association in Southern Africa. We explored the determinants of metabolic syndrome (MetS) among treatment-naïve adults living with and without HIV in Southern Africa. Treatment-naïve PLWH and people living without HIV (PLWOH) ≥30 years were consecutively enrolled from primary care clinics in Zambia and Zimbabwe. PLWOH were seronegative partners or persons presenting for HIV testing. We defined MetS as the presence of central obesity plus any two of the following: raised blood pressure, impaired fasting glucose, reduced high-density lipoprotein cholesterol and raised triglycerides, as defined by the International Diabetes Federation. We used logistic regression to determine factors associated with MetS. Between August 2019 and March 2022, we screened 1285 adults and enrolled 420 (47%) PLWH and 481 (53%) PLWOH. The median age was similar between PLWH and PLWOH (40 vs. 38 years, p < 0.24). In PLWH, the median CD4 We report a high prevalence of MetS and central obesity among females in urban Zambia and Zimbabwe. Lifestyle factors and older age appear to be the strongest predictors of MetS in our population, with no evident difference in MetS prevalence between treatment-naïve PLWH and PLWOH.
Identifiants
pubmed: 36522287
doi: 10.1002/jia2.26047
pmc: PMC9755006
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e26047Subventions
Organisme : NIAID NIH HHS
ID : U01 AI069924
Pays : United States
Informations de copyright
© 2022 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.
Références
Curr Hypertens Rep. 2018 Feb 26;20(2):12
pubmed: 29480368
Circulation. 2019 Jun 18;139(25):e1082-e1143
pubmed: 30586774
Medicine (Baltimore). 2020 Jul 2;99(27):e20845
pubmed: 32629671
J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):438-445
pubmed: 27391387
J Acquir Immune Defic Syndr (1988). 1994 Nov;7(11):1149-56
pubmed: 7932082
Int J Hypertens. 2011;2011:193719
pubmed: 21747973
Eur J Prev Cardiol. 2017 Aug;24(12):1297-1307
pubmed: 28578613
AIDS Patient Care STDS. 2018 Jun;32(6):215-222
pubmed: 29851503
Proc Nutr Soc. 2015 Nov;74(4):478-86
pubmed: 25686639
Medicine (Baltimore). 2021 Apr 9;100(14):e25236
pubmed: 33832083
Clin Infect Dis. 2014 Dec 15;59(12):1787-97
pubmed: 25182245
Trop Med Int Health. 2017 Jun;22(6):725-733
pubmed: 28342180
Alcohol Clin Exp Res. 2007 Jul;31(7):1208-17
pubmed: 17451397
Syst Rev. 2019 Jan 3;8(1):4
pubmed: 30606249
Ann Intern Med. 2021 Jun;174(6):758-767
pubmed: 33721521
Biol Sex Differ. 2019 Jul 1;10(1):30
pubmed: 31262349
Metab Syndr Relat Disord. 2012 Oct;10(5):373-9
pubmed: 22799758
BMJ Open. 2020 May 15;10(5):e035246
pubmed: 32414825
Open Forum Infect Dis. 2021 Dec 08;9(1):ofab621
pubmed: 35028335
PLoS One. 2021 Nov 15;16(11):e0255652
pubmed: 34780476
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
J Am Coll Cardiol. 2017 Jan 3;69(1):73-82
pubmed: 28057253
Dis Model Mech. 2009 May-Jun;2(5-6):231-7
pubmed: 19407331
Lancet HIV. 2020 Oct;7(10):e666-e676
pubmed: 33010240
AIDS Res Ther. 2013 Dec 13;10(1):32
pubmed: 24330597
J Intern Med. 2020 Sep;288(3):271-283
pubmed: 32367627