Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis.

Journal

NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846

Informations de publication

Date de publication:
16 Dec 2022
Historique:
received: 04 11 2021
accepted: 05 12 2022
entrez: 15 12 2022
pubmed: 16 12 2022
medline: 16 12 2022
Statut: epublish

Résumé

Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of autologous chondrocyte cell-sheets along with open-wedge high tibial osteotomy promoted hyaline cartilage repair in humans. Here we describe our regenerative therapy for OAK using polydactyly-derived allogeneic chondrocyte cell-sheets (PD sheets) and temperature-responsive culture inserts. Ten patients with OAK and cartilage defects categorized arthroscopically as Outerbridge grade III or IV received the therapy. Cartilage viscoelasticity and thickness were assessed before and after transplantation. Arthroscopic biopsies obtained 12 months after transplantation were analyzed histologically. Gene expression was analyzed to evaluate the PD sheets. In this small initial longitudinal series, PD sheet transplantation was effective in treating OAK, as indicated by changes in cartilage properties. Gene marker sets in PD sheets may predict outcomes after therapy and provide markers for the selection of donor cells. This combined surgery may be an ideal regenerative therapy with disease-modifying effects in OAK patients.

Identifiants

DOI: 10.1038/s41536-022-00272-1 PMID: 36522336 PMC: PMC9755241
pubmed: 36522336
doi: 10.1038/s41536-022-00272-1
pii: 10.1038/s41536-022-00272-1
pmc: PMC9755241
doi:

Types de publication

Journal Article

Langues

eng

Pagination

71

Subventions

Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP15bk0104001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP17bk0104063
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20bk0104101

Informations de copyright

© 2022. The Author(s).

Références

NPJ Regen Med. 2021 Oct 15;6(1):65
pubmed: 34654830
Radiol Clin North Am. 2004 Jan;42(1):1-9, v
pubmed: 15049520
Knee. 2007 Dec;14(6):465-71
pubmed: 17822904
Inflamm Regen. 2017 Nov 01;37:22
pubmed: 29259721
Cartilage. 2021 Dec;13(1_suppl):571S-587S
pubmed: 31422674
Arthroscopy. 1997 Feb;13(1):9-17
pubmed: 9043599
Am J Sports Med. 2010 May;38(5):880-90
pubmed: 20203290
Biochem Biophys Res Commun. 2006 Oct 20;349(2):723-31
pubmed: 16949051
J Tissue Eng Regen Med. 2016 Jun;10(6):486-95
pubmed: 23868865
Regen Ther. 2018 Aug 24;9:24-31
pubmed: 30525072
Arthroscopy. 2009 Jan;25(1):46-53
pubmed: 19111218
Arthroplast Today. 2020 Dec 21;7:7-10
pubmed: 33521190
Sci Rep. 2019 Mar 12;9(1):4275
pubmed: 30862915
Int J Mol Sci. 2019 Dec 24;21(1):
pubmed: 31878307
BMC Biotechnol. 2013 Jul 25;13:58
pubmed: 23886356
Biomaterials. 1995 Mar;16(4):297-303
pubmed: 7772669
Educ Health (Abingdon). 2003 Jul;16(2):230
pubmed: 14741909
J Tissue Eng Regen Med. 2020 Sep;14(9):1296-1306
pubmed: 32652894
Clin Orthop Relat Res. 1992 Apr;(277):210-6
pubmed: 1555344
Biomaterials. 2012 May;33(15):3846-51
pubmed: 22369960
Acta Orthop Scand. 1992 Aug;63(4):413-6
pubmed: 1529692
Eur Cell Mater. 2007 May 22;13:87-92
pubmed: 17516420
J Orthop Res. 1992 Jan;10(1):58-61
pubmed: 1727936
Arthroscopy. 2015 Jul;31(7):1279-88
pubmed: 25861712
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S80-92
pubmed: 20864026
Biomaterials. 2014 Feb;35(7):2199-206
pubmed: 24360579
Arthritis Res Ther. 2015 Dec 30;17:383
pubmed: 26717992
NPJ Regen Med. 2019 Feb 21;4:4
pubmed: 30820353
J Tissue Eng Regen Med. 2015 Jan;9(1):24-30
pubmed: 23165985
J Tissue Eng Regen Med. 2017 Dec;11(12):3437-3444
pubmed: 28198149
J Bone Joint Surg Am. 1971 Apr;53(3):523-37
pubmed: 5580011
Clin Orthop Relat Res. 1985 Sep;(198):43-9
pubmed: 4028566
Biomaterials. 2012 Jul;33(21):5278-86
pubmed: 22551484
Regen Ther. 2020 May 14;14:215-221
pubmed: 32435673
Health Qual Life Outcomes. 2003 Nov 03;1:64
pubmed: 14613558
BMC Biotechnol. 2009 Mar 06;9:17
pubmed: 19267909
J Tissue Eng Regen Med. 2018 Oct;12(10):2067-2076
pubmed: 30058138
NPJ Regen Med. 2019 May 30;4:12
pubmed: 31231546
J Biomed Mater Res. 1993 Oct;27(10):1243-51
pubmed: 8245039
J Tissue Eng Regen Med. 2018 Nov;12(11):2179-2187
pubmed: 30075064

Auteurs

Kosuke Hamahashi (K)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Eriko Toyoda (E)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.
ORCID: 0000-0002-8789-2501

Miya Ishihara (M)

Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Genya Mitani (G)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Tomonori Takagaki (T)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Nagatoshi Kaneshiro (N)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Miki Maehara (M)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Takumi Takahashi (T)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.
ORCID: 0000-0003-0217-1324

Eri Okada (E)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Ayako Watanabe (A)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.

Yoshihiko Nakamura (Y)

Cell Processing Center, Tokai University Hospital, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Reiko Kato (R)

National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.

Ryo Matoba (R)

DNA Chip Research Inc., 1-15-1 Kaigan, Suzue Baydium 5F Minato-ku, Tokyo, 105-0022, Japan.

Takehiko Takagi (T)

National Center for Child Health and Development, 2-10-1 Okura,Setagaya-ku, Tokyo, 157-8535, Japan.

Hidenori Akutsu (H)

National Center for Child Health and Development, 2-10-1 Okura,Setagaya-ku, Tokyo, 157-8535, Japan.

Akihiro Umezawa (A)

National Center for Child Health and Development, 2-10-1 Okura,Setagaya-ku, Tokyo, 157-8535, Japan.

Hiroyuki Kobayashi (H)

Department of Clinical Pharmacology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Tadashi Akamatsu (T)

Department of Plastic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Masayuki Yamato (M)

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
ORCID: 0000-0002-3146-1024

Teruo Okano (T)

Cell Sheet Tissue Engineering Center, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000, East Salt Lake, UT, 84112, USA.

Masahiko Watanabe (M)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan.
ORCID: 0000-0001-9038-0446

Masato Sato (M)

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. sato-m@is.icc.u-tokai.ac.jp.
Center for Musculoskeletal innovative Research and Advancement (C-MiRA), Tokai University Graduate School, Isehara, Kanagawa, 259-1193, Japan. sato-m@is.icc.u-tokai.ac.jp.
ORCID: 0000-0003-4049-7325

Classifications MeSH