Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism.
Fusobacterium nucleatum
colorectal cancer
immune microenvironment
metabolic reprogramming
metastasis
prevention
stemness
therapy response
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
08
2022
accepted:
09
11
2022
entrez:
16
12
2022
pubmed:
17
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
Colorectal cancer(CRC) is the third most frequent malignant tumor. The gut microbiome acts as a vital component of CRC etiology. Fusobacterium nucleatum(Fn) is a key member of colorectal cancer-associated bacteria. But we lack a systematic and in-depth understanding on its role in CRC evolution. In this article, We reviewed the abundance changes and distribution of Fn in CRC occurrence and development, potential effect of Fn in the initiation of CRC, the source of intratumoral Fn and the cause of its tropism to CRC. In addition, We described the mechanism by which Fn promotes the malignant biological behavior of CRC, affects CRC response to therapy, and shapes the tumor immune microenvironment in great detail. Based on the relationship between Fn and CRC, we proposed strategies for CRC prevention and treatment, and discussed the feasibility and limitations of specific cases, to gain insights into further basic and clinical research in the future.
Identifiants
pubmed: 36523635
doi: 10.3389/fcimb.2022.1020583
pmc: PMC9745098
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1020583Informations de copyright
Copyright © 2022 Ou, Wang, Tao, Luo, Ye, Ran, Guan, Wang, Hu and Huang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Gut. 2011 Jan;60(1):34-40
pubmed: 19926616
Gastroenterology. 2017 May;152(6):1419-1433.e5
pubmed: 28126350
EMBO Rep. 2019 Apr;20(4):
pubmed: 30833345
Infect Immun. 1995 Dec;63(12):4830-6
pubmed: 7591143
Front Immunol. 2019 Jun 12;10:1324
pubmed: 31249571
Trends Immunol. 2013 Apr;34(4):182-91
pubmed: 23414611
Oncol Lett. 2021 Feb;21(2):143
pubmed: 33552262
Eur J Clin Microbiol Infect Dis. 2002 Dec;21(12):884-6
pubmed: 12525925
J Pediatric Infect Dis Soc. 2015 Dec;4(4):e155-9
pubmed: 26407282
Infect Immun. 2016 Jun 23;84(7):2141-2148
pubmed: 27185790
Nature. 2018 Mar 29;555(7698):623-628
pubmed: 29555994
BMC Biol. 2016 Mar 16;14:20
pubmed: 26984638
Dalton Trans. 2022 May 10;51(18):7040-7052
pubmed: 35319052
Cancer Res. 2021 Dec 15;81(24):6157-6170
pubmed: 34645607
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Cell Host Microbe. 2013 Aug 14;14(2):195-206
pubmed: 23954158
Cell Stem Cell. 2010 Sep 3;7(3):279-82
pubmed: 20804964
Cancer Immunol Res. 2018 Nov;6(11):1327-1336
pubmed: 30228205
Oncoimmunology. 2019 Mar 27;8(6):e1581531
pubmed: 31069151
Cancer Immunol Immunother. 2018 Oct;67(10):1635-1646
pubmed: 30121899
Gut Microbes. 2022 Jan-Dec;14(1):2038852
pubmed: 35220887
Gut Microbes. 2021 Jan-Dec;13(1):1941710
pubmed: 34225577
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Int J Cell Biol. 2012;2012:340296
pubmed: 22272201
Gastroenterology. 2017 Mar;152(4):851-866.e24
pubmed: 27876571
Lancet. 2019 Oct 19;394(10207):1467-1480
pubmed: 31631858
Clin Transl Sci. 2009 Jun;2(3):199-205
pubmed: 20443893
Nat Rev Cancer. 2013 Dec;13(12):858-70
pubmed: 24263189
Oncotarget. 2017 May 9;8(19):31802-31814
pubmed: 28423670
Cancers (Basel). 2021 Feb 25;13(5):
pubmed: 33668827
Genome Res. 2012 Feb;22(2):299-306
pubmed: 22009989
Gut. 2016 Dec;65(12):1973-1980
pubmed: 26311717
Signal Transduct Target Ther. 2021 Nov 19;6(1):398
pubmed: 34795206
J Clin Microbiol. 2015 Apr;53(4):1399-402
pubmed: 25653408
Cell Rep. 2015 Mar 24;10(11):1861-71
pubmed: 25801025
JAMA Oncol. 2015 Aug;1(5):653-61
pubmed: 26181352
J Cell Sci. 2004 Jan 15;117(Pt 2):133-41
pubmed: 14676269
J Oncol. 2019 Sep 29;2019:5636272
pubmed: 31662752
Sci Rep. 2017 Sep 5;7(1):10566
pubmed: 28874771
J Cancer Prev. 2017 Jun;22(2):108-114
pubmed: 28698865
J Neurosurg. 2003 Oct;99(4):693-700
pubmed: 14567605
Sci Adv. 2020 May 15;6(20):eaba1590
pubmed: 32440552
J Gastroenterol. 2015 Feb;50(2):167-79
pubmed: 24811328
Biomed Pharmacother. 2019 Aug;116:108988
pubmed: 31112873
J Gastroenterol. 2018 Apr;53(4):517-524
pubmed: 28823057
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Nat Med. 2017 Oct 6;23(10):1124-1134
pubmed: 28985214
Int J Clin Exp Pathol. 2020 Jul 01;13(7):1819-1828
pubmed: 32782710
Gut Microbes. 2021 Jan-Dec;13(1):1987780
pubmed: 34781821
Cancers (Basel). 2020 Sep 23;12(10):
pubmed: 32977534
PLoS Comput Biol. 2012;8(7):e1002606
pubmed: 22807668
Front Pharmacol. 2022 Mar 04;13:841918
pubmed: 35308221
Front Cell Infect Microbiol. 2020 Aug 07;10:400
pubmed: 32850497
Science. 2017 Dec 15;358(6369):1443-1448
pubmed: 29170280
Immunol Rev. 2014 Jul;260(1):35-49
pubmed: 24942680
Digestion. 2022;103(2):141-149
pubmed: 34619680
Cancer Res. 2017 May 15;77(10):2620-2632
pubmed: 28416491
Nat Commun. 2022 Mar 10;13(1):1248
pubmed: 35273176
Theranostics. 2020 Jan 1;10(1):323-339
pubmed: 31903123
J Gastroenterol Hepatol. 2020 Mar;35(3):433-437
pubmed: 31609493
Cancer Immunol Immunother. 2021 Jan;70(1):47-59
pubmed: 32623478
FEMS Immunol Med Microbiol. 2009 Jun;56(1):67-72
pubmed: 19484811
J Oral Microbiol. 2019 Jan 24;11(1):1565043
pubmed: 30719234
Trends Cell Biol. 2018 Feb;28(2):113-127
pubmed: 29103884
Nature. 2008 Jan 3;451(7174):76-80
pubmed: 18172499
Acta Obstet Gynecol Scand. 1988;67(6):513-7
pubmed: 3071072
Dig Dis Sci. 2018 May;63(5):1210-1218
pubmed: 29508166
Biochem Pharmacol. 2017 Jul 1;135:12-21
pubmed: 28237650
Gut. 2022 Mar;71(3):521-533
pubmed: 33685966
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Annu Rev Pathol. 2016 May 23;11:47-76
pubmed: 27193450
Int J Cancer. 2016 Sep 15;139(6):1318-26
pubmed: 27130618
Cell Host Microbe. 2016 Aug 10;20(2):215-25
pubmed: 27512904
J Exp Clin Cancer Res. 2019 Jan 10;38(1):14
pubmed: 30630498
Cancer Res. 2019 Apr 15;79(8):1822-1830
pubmed: 30803995
Hepatol Res. 2011 Feb;41(2):194-6
pubmed: 21269389
Gut. 2012 Jun;61(6):847-54
pubmed: 22427238
EBioMedicine. 2020 Nov;61:103037
pubmed: 33039709
Mol Microbiol. 2011 Dec;82(6):1468-80
pubmed: 22040113
Adv Sci (Weinh). 2022 Apr;9(12):e2105222
pubmed: 35170250
Nat Metab. 2022 Apr;4(4):458-475
pubmed: 35437333
Gut Microbes. 2021 Jan-Dec;13(1):1980347
pubmed: 34632963
Biomed Res Int. 2020 Jan 25;2020:9037217
pubmed: 32090113
Curr Issues Mol Biol. 2011;13(2):25-36
pubmed: 21220789
mBio. 2022 Feb 8;:e0299121
pubmed: 35130731
World J Gastroenterol. 2016 Mar 21;22(11):3227-33
pubmed: 27004000
J Ethnopharmacol. 2009 Oct 29;126(1):5-17
pubmed: 19686830
Gut. 2021 Nov;70(11):2123-2137
pubmed: 33318144
Gut. 2022 Aug;71(8):1600-1612
pubmed: 34497144
Gut. 2020 Nov 10;:
pubmed: 33172926
Science. 2016 Jun 24;352(6293):1506
pubmed: 27339963
Cancer Prev Res (Phila). 2017 Jul;10(7):398-409
pubmed: 28483840
Oral Microbiol Immunol. 2006 Jun;21(3):190-6
pubmed: 16626377
PLoS One. 2013;8(1):e53653
pubmed: 23335968
Microb Biotechnol. 2021 Sep;14(5):2176-2186
pubmed: 34309194
Virchows Arch. 2017 Sep;471(3):329-336
pubmed: 28597080
J Med Microbiol. 2008 May;57(Pt 5):668-671
pubmed: 18436604
Med Sci Monit. 2017 Sep 14;23:4422-4430
pubmed: 28904330
Curr Protoc Microbiol. 2006 Jan;Chapter 13:Unit 13A.1
pubmed: 18770577
Mol Cell. 2008 Jun 20;30(6):689-700
pubmed: 18570872
Oncotarget. 2015 Oct 13;6(31):32013-26
pubmed: 26397137
PLoS One. 2015 Mar 09;10(3):e0119462
pubmed: 25751261
Int J Cancer. 2015 Sep 15;137(6):1258-68
pubmed: 25703934
Cancers (Basel). 2021 Apr 18;13(8):
pubmed: 33919517
J Bacteriol. 2010 Oct;192(19):5002-17
pubmed: 20656903
Br J Pharmacol. 2009 Sep;158(2):610-20
pubmed: 19732064
Nat Rev Gastroenterol Hepatol. 2015 Jul;12(7):401-9
pubmed: 25963511
Ann Surg Oncol. 2018 Oct;25(11):3389-3395
pubmed: 30062471
Gut. 2003 Jan;52(1):79-83
pubmed: 12477765
Cell. 2017 Jul 27;170(3):548-563.e16
pubmed: 28753429
Eur J Pharm Sci. 2020 Sep 1;152:105464
pubmed: 32668313
Cell Host Microbe. 2013 Aug 14;14(2):207-15
pubmed: 23954159
Inflamm Bowel Dis. 2011 Sep;17(9):1971-8
pubmed: 21830275
Clin Transl Gastroenterol. 2016 Nov 3;7(11):e200
pubmed: 27811909
Cancer Res. 2014 Mar 1;74(5):1311-8
pubmed: 24385213
Cancer Epidemiol Biomarkers Prev. 2022 Jan;31(1):210-220
pubmed: 34737207
Cancer Discov. 2019 Sep;9(9):1167-1181
pubmed: 31434711
Nat Biomed Eng. 2018 Nov;2(11):841-849
pubmed: 30854250
World J Gastroenterol. 2021 Aug 7;27(29):4879-4889
pubmed: 34447232
Eur J Clin Microbiol Infect Dis. 2017 Nov;36(11):2073-2083
pubmed: 28600626
Genome Res. 2012 Feb;22(2):292-8
pubmed: 22009990
J Clin Microbiol. 1983 Feb;17(2):349-51
pubmed: 6833485
Sci Rep. 2017 Sep 14;7(1):11590
pubmed: 28912574
Infect Immun. 2010 Nov;78(11):4773-8
pubmed: 20823215
Cancer Sci. 2021 Nov;112(11):4470-4477
pubmed: 34464993
Clin Infect Dis. 1996 Feb;22(2):384-5
pubmed: 8838210
Clin Cancer Res. 2021 May 15;27(10):2816-2826
pubmed: 33632927
Int Immunopharmacol. 2019 Sep;74:105724
pubmed: 31272064
J Immunol. 1984 May;132(5):2357-62
pubmed: 6715883
Carcinogenesis. 2017 Aug 1;38(8):781-788
pubmed: 28582482
Rev Gastroenterol Mex (Engl Ed). 2022 Jul-Sep;87(3):277-284
pubmed: 34312118
Int J Cancer. 2019 Oct 15;145(8):2032-2041
pubmed: 30474116
Front Cell Infect Microbiol. 2021 Jul 15;11:692544
pubmed: 34336716
Gut. 2019 Jul;68(7):1335-1337
pubmed: 29934439
Eur J Clin Microbiol Infect Dis. 2014 Aug;33(8):1381-90
pubmed: 24599709
Cancer Res. 2021 Sep 1;81(17):4485-4498
pubmed: 34162680
Chem Res Toxicol. 2019 Nov 18;32(11):2227-2237
pubmed: 31569943
Sci Rep. 2016 Apr 29;6:25271
pubmed: 27125587
Infect Immun. 2000 Apr;68(4):1893-8
pubmed: 10722579
Immunity. 2015 Feb 17;42(2):344-355
pubmed: 25680274
Sci Signal. 2020 Jul 21;13(641):
pubmed: 32694172
Gut Microbes. 2020 May 3;11(3):511-525
pubmed: 31910722
Front Immunol. 2021 May 21;12:658681
pubmed: 34093546