MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.

To evaluate the clinical validity of free water (FW), a diffusion tensor imaging-based biomarker kit proposed by the MarkVCID consortium, by investigating the association between mean FW (mFW) and executive function. Baseline mFW was related to a baseline composite measure of executive function (EFC), adjusting for relevant covariates, in three MarkVCID sub-cohorts, and replicated in five, large, independent legacy cohorts. In addition, we tested whether baseline mFW predicted accelerated EFC score decline (mean follow-up time: 1.29 years). Higher mFW was found to be associated with lower EFC scores in MarkVCID legacy and sub-cohorts ( mFW is a sensitive biomarker of cognitive decline, providing a strong clinical rational for its use as a marker of white matter (WM) injury in multi-site observational studies and clinical trials of vascular cognitive impairment and dementia (VCID).

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© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

Déclaration de conflit d'intérêts

Dr. Pauline Maillard has no conflict of interest to report. Laura J. Hillmer has no conflict of interest to report. Dr. Hanzhang Lu has no conflict of interest to report. Dr. Konstantinos Arfanakis is on the advisory board for External Advisory Committee, NIH‐funded clinical research study titled “Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY Network (DISCOVERY).” Dr. Brian T. Gold has no conflict of interest to report. Dr. Christopher E. Bauer has no conflict of interest to report. Dr. Lara Stables has no conflict of interest to report. Dr. Danny JJ Wang has no conflict of interest to report. Dr. Sudha Seshadri is a consultant for Biogen. Dr. Claudia L. Satizabal has received support for attending meetings and/or travel from the NIH (payment to Dr. Satizabal). Dr. Alexa Beiser has no conflict of interest to report. Dr. Myriam Fornage has no conflict of interest to report. Dr. Thomas H. Mosley has no conflict of interest to report. Dr. Gary A. Rosenberg has no conflict of interest to report. Dr. Mohamad Habes is a consultant for Biogen on ARIA. Baljeet Singh has no conflict of interest to report. Dr. Joel H. Kramer has received royalties from Pearson, Inc. Dr. Adam M. Staffaroni is a consultant to Passage Bio and Takeda. Herpreet Singh has no conflict of interest to report. Kristin Schwab has no conflict of interest to report. Dr. Karl G. Helmer has no conflict of interest to report. Dr. Steven M. Greenberg is a consultant for Roche (payment to Dr. Greenberg) and Washington University/IQVIA (payment to Dr. Greenberg), Bayer (payment to Dr. Greenberg), and Biogen (payment to Dr. Greenberg), and receives royalties or licenses from Up‐To‐Date (payment to Dr. Greenberg). Dr. Charles DeCarli is a consultant to Novartis on a safety trial for heart failure. Dr. Arvind Caprihan has no conflict of interest to report. Author disclosures are available in the supporting information.