Should cardiovascular comorbidities be a contraindication for pulmonary metastasectomy?
Lung metastases
cardiovascular comorbidities (CVC)
pulmonary metastasectomy (PM)
thoracic surgery
Journal
Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
29
03
2022
accepted:
05
08
2022
entrez:
16
12
2022
pubmed:
17
12
2022
medline:
17
12
2022
Statut:
ppublish
Résumé
Limited information is available about the impact of cardiovascular comorbidities (CVC) on the postoperative course of patients undergoing pulmonary metastasectomy (PM). In this study, we aim to compare the postoperative morbidity, mortality, and the long-term survival of patients with and without CVC undergoing PM. A retrospective monocentric study was conducted including 760 patients who underwent PM in curative intention. Patients were divided into two groups depending on the presence of CVC. The data from 164 patients with CVC (21.6%) and 596 patients without CVC (78.4%) were investigated. In both groups, zero in-hospital-mortality and limited 30-day mortality was detected. Postoperative complications occurred more often in patients with CVC (N=47, 28.7% Resection of pulmonary metastases can be performed safely in selected patients with stable CVC. The presence of CVC in patients undergoing PM is associated with reduced overall survival compared to patients without CVC in the long term follow up. However, a prolonged 5-year survival rate of 68% could be achieved.
Sections du résumé
Background
UNASSIGNED
Limited information is available about the impact of cardiovascular comorbidities (CVC) on the postoperative course of patients undergoing pulmonary metastasectomy (PM). In this study, we aim to compare the postoperative morbidity, mortality, and the long-term survival of patients with and without CVC undergoing PM.
Methods
UNASSIGNED
A retrospective monocentric study was conducted including 760 patients who underwent PM in curative intention. Patients were divided into two groups depending on the presence of CVC.
Results
UNASSIGNED
The data from 164 patients with CVC (21.6%) and 596 patients without CVC (78.4%) were investigated. In both groups, zero in-hospital-mortality and limited 30-day mortality was detected. Postoperative complications occurred more often in patients with CVC (N=47, 28.7%
Conclusions
UNASSIGNED
Resection of pulmonary metastases can be performed safely in selected patients with stable CVC. The presence of CVC in patients undergoing PM is associated with reduced overall survival compared to patients without CVC in the long term follow up. However, a prolonged 5-year survival rate of 68% could be achieved.
Identifiants
pubmed: 36524092
doi: 10.21037/jtd-22-409
pii: jtd-14-11-4266
pmc: PMC9745539
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4266-4275Informations de copyright
2022 Journal of Thoracic Disease. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-22-409/coif). The authors have no conflicts of interest to declare.
Références
Int J Colorectal Dis. 2018 Oct;33(10):1401-1409
pubmed: 30056558
Lasers Med Sci. 2020 Apr;35(3):611-620
pubmed: 31410616
Thorax. 2014 Oct;69(10):946-9
pubmed: 24415715
Eur J Anaesthesiol. 2015 Feb;32(2):88-105
pubmed: 25058504
Ann Thorac Surg. 2007 Jul;84(1):324-38
pubmed: 17588454
Ann Thorac Surg. 2010 Sep;90(3):936-42; discussion 942
pubmed: 20732521
Eur J Cardiothorac Surg. 1999 Mar;15(3):314-9
pubmed: 10333029
J Thorac Dis. 2019 Aug;11(8):3241-3249
pubmed: 31559026
J Thorac Dis. 2018 Jan;10(1):314-320
pubmed: 29600062
Gen Thorac Cardiovasc Surg. 2022 Mar;70(3):248-256
pubmed: 34554366
Langenbecks Arch Surg. 2013 Aug;398(6):903-7
pubmed: 23760754
Eur J Cardiothorac Surg. 2022 Jun 15;62(1):
pubmed: 35415756
Eur J Cardiothorac Surg. 2003 May;23(5):811-7
pubmed: 12754038
Clin Transl Oncol. 2019 Sep;21(9):1220-1230
pubmed: 30680608
Eur J Cardiothorac Surg. 2014 Apr;45(4):671-6
pubmed: 24092503
Ann Thorac Surg. 2017 Sep;104(3):979-987
pubmed: 28577846
Surg Today. 2017 Jan;47(1):27-34
pubmed: 27194125
Ann Thorac Surg. 2007 Jul;84(1):203-10
pubmed: 17588413
Eur J Cardiothorac Surg. 2009 Mar;35(3):439-43
pubmed: 19081729
Int J Clin Oncol. 2022 Aug;27(8):1238-1246
pubmed: 35226235