Lower Hepatic Fat Is Associated With Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention.

Humans Prediabetic State / metabolism Insulin Secretion Blood Glucose / metabolism Liver / metabolism Insulin Resistance Life Style Insulin / metabolism

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
01 03 2023
Historique:
received: 09 05 2022
accepted: 12 12 2022
pubmed: 17 12 2022
medline: 25 2 2023
entrez: 16 12 2022
Statut: ppublish

Résumé

The objective of this work was to investigate whether impaired insulin secretion can be restored by lifestyle intervention in specific subphenotypes of prediabetes. We assigned 1,045 participants from the Prediabetes Lifestyle Intervention Study (PLIS) to six recently established prediabetes clusters. Insulin secretion was assessed by a C-peptide-based index derived from oral glucose tolerance tests and modeled from three time points during a 1-year intervention. We also analyzed the change of glycemia, insulin sensitivity, and liver fat. All prediabetes high-risk clusters (cluster 3, 5, and 6) had improved glycemic traits during the lifestyle intervention, whereas insulin secretion only increased in clusters 3 and 5 (P < 0.001); however, high liver fat in cluster 5 was associated with a failure to improve insulin secretion (Pinteraction < 0.001). Thus, interventions to reduce liver fat have the potential to improve insulin secretion in a defined subgroup of prediabetes.

Identifiants

DOI: 10.2337/db22-0441 PMID: 36525512 PMC: PMC9935494
pubmed: 36525512
pii: 148155
doi: 10.2337/db22-0441
pmc: PMC9935494
doi:

Substances chimiques

Blood Glucose 0
Insulin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

362-366

Informations de copyright

© 2023 by the American Diabetes Association.

Auteurs

Robert Wagner (R)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Martin Heni (M)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Division of Endocrinology and Diabetology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital of Tübingen, Tübingen, Germany.

Konstantinos Kantartzis (K)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

Arvid Sandforth (A)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

Jürgen Machann (J)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Section on Experimental Radiology, Department of Radiology, University of Tübingen, Tübingen, Germany.

Fritz Schick (F)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Section on Experimental Radiology, Department of Radiology, University of Tübingen, Tübingen, Germany.

Andreas Peter (A)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital of Tübingen, Tübingen, Germany.

Louise Fritsche (L)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

Julia Szendrödi (J)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.
Institute for Diabetes and Cancer, IDC Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes Program, Neuherberg, Germany.

Andreas F H Pfeiffer (AFH)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Endocrinology & Metabolism, Charité Universitätsmedizin Berlin, Berlin, Germany.

Annette Schürmann (A)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.

Matthias Blüher (M)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Medicine, Endocrinology and Nephrology, Universität Leipzig, Leipzig, Germany.

Hans Hauner (H)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.

Jochen Seissler (J)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Diabetes Center, Medical Department 4, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

Stefan Bornstein (S)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany.

Michael Roden (M)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0001-8200-6382

Norbert Stefan (N)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

Andreas L Birkenfeld (AL)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

Morris F White (MF)

Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA.

Hans-Ulrich Häring (HU)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
ORCID: 0000-0001-6876-5067

Andreas Fritsche (A)

German Center for Diabetes Research (DZD), Neuherberg, Germany.
Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University Tübingen, Tübingen, Germany.
Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Maladies endocriniennes › Diabète › État prédiabétique › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Phénomènes physiologiques › Sécrétion d'insuline › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Système digestif › Foie › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Lower Hepatic Fat Is Associated With Improved...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Lower Hepatic Fat Is Associated With Improved...