Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder.
anxiety disorders
cognitive-behavioral therapy
magnetic resonance imaging
neuroimaging
obsessive-compulsive disorder
Journal
Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 1527-5418
Titre abrégé: J Am Acad Child Adolesc Psychiatry
Pays: United States
ID NLM: 8704565
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
13
03
2022
revised:
26
07
2022
accepted:
06
12
2022
pmc-release:
01
04
2024
medline:
3
4
2023
pubmed:
17
12
2022
entrez:
16
12
2022
Statut:
ppublish
Résumé
Cognitive-behavioral therapy (CBT) is considered a first-line treatment for obsessive-compulsive disorder (OCD) in pediatric and adult populations. Nevertheless, some patients show partial or null response. The identification of predictors of CBT response may improve clinical management of patients with OCD. Here, we aimed to identify structural magnetic resonance imaging (MRI) predictors of CBT response in 2 large series of children and adults with OCD from the worldwide ENIGMA-OCD consortium. Data from 16 datasets from 13 international sites were included in the study. We assessed which variations in baseline cortical thickness, cortical surface area, and subcortical volume predicted response to CBT (percentage of baseline to post-treatment symptom reduction) in 2 samples totaling 168 children and adolescents (age range 5-17.5 years) and 318 adult patients (age range 18-63 years) with OCD. Mixed linear models with random intercept were used to account for potential cross-site differences in imaging values. Significant results were observed exclusively in the pediatric sample. Right prefrontal cortex thickness was positively associated with the percentage of CBT response. In a post hoc analysis, we observed that the specific changes accounting for this relationship were a higher thickness of the frontal pole and the rostral middle frontal gyrus. We observed no significant effects of age, sex, or medication on our findings. Higher cortical thickness in specific right prefrontal cortex regions may be important for CBT response in children with OCD. Our findings suggest that the right prefrontal cortex plays a relevant role in the mechanisms of action of CBT in children.
Identifiants
pubmed: 36526161
pii: S0890-8567(22)01972-4
doi: 10.1016/j.jaac.2022.07.865
pmc: PMC10065927
mid: NIHMS1857152
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-414Subventions
Organisme : NIMH NIH HHS
ID : K23 MH094613
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Investigateurs
Eva Real
(E)
Cinto Segalas
(C)
Astrid Morer
(A)
Silvia Brem
(S)
Sonia Ferreira
(S)
Pedro Silva Moreira
(PS)
Kristen Hagen
(K)
Sayo Hamatani
(S)
Jumpei Takahashi
(J)
Tokiko Yoshida
(T)
Maria Alice de Mathis
(MA)
Euripedes C Miguel
(EC)
Jose C Pariente
(JC)
Jinsong Tang
(J)
Informations de copyright
Copyright © 2022 American Academy of Child and Adolescent Psychiatry. All rights reserved.
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