Assessment of Adiponectin and Sperm Function Parameters in Obese and Non-Obese: A Comprehensive Study.
Adiponectin
Chromatin
Obesity
Sperm
Viability
Journal
Cell journal
ISSN: 2228-5806
Titre abrégé: Cell J
Pays: Iran
ID NLM: 101566618
Informations de publication
Date de publication:
01 Dec 2022
01 Dec 2022
Historique:
received:
08
07
2022
entrez:
17
12
2022
pubmed:
18
12
2022
medline:
18
12
2022
Statut:
epublish
Résumé
The role of adiponectin in sperm function is inconclusive and there is a paucity of evidence. Obesity shows an ambiguous influence on sperm motility, and male subfertility. The aim of this study was to compare the role of adiponectin and sperm functional parameters among obese and non-obese men. In this comprehensive study, 64 male patients were included, and were classified as nonobese [body mass index (BMI)< 24.9 kg/m In obese men, adiponectin gene expression (P<0.0001) and protein levels (P<0.001) were significantly lower compared to the non-obese group. Additionally, sperm motility, was significantly lower in the obese group. The rapid progressive (RP) motility was less in obese men in comparison to the non-obese group (P<0.001). Sperm count and morphology were not significantly different in the two groups. DNA denaturation and DNA fragmentation were significantly more frequent in the obese group than in non-obese men (P<0.05) and (P<0.01), respectively. The obese men showed significantly lower sperm viability compared to the non-obese group (P<0.05). This study showed no significant correlation between the evaluated variables (sperm parameter, sperm viability, DNA fragmentation and integrity), and obesity in men. Based on these results, adiponectin may potentially play positive role in sperm function for acquiring fertility.
Identifiants
pubmed: 36527343
doi: 10.22074/cellj.2022.557337.1044
pmc: PMC9790071
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
715-722Références
JAMA. 2013 Jan 2;309(1):71-82
pubmed: 23280227
Hum Reprod Update. 2010 May-Jun;16(3):231-45
pubmed: 19934213
J Nutr Biochem. 2022 May;103:108966
pubmed: 35181443
Proc Nutr Soc. 2001 Aug;60(3):329-39
pubmed: 11681807
Andrology. 2020 Sep;8(5):1471-1485
pubmed: 32438512
Hum Reprod. 2009 Jul;24(7):1561-8
pubmed: 19351657
Hum Exp Toxicol. 2018 Mar;37(3):247-255
pubmed: 28413887
Cell Tissue Bank. 2019 Sep;20(3):367-378
pubmed: 31139967
Int J Reprod Biomed. 2016 Jun;14(6):397-402
pubmed: 27525323
Reprod Biol Endocrinol. 2018 Sep 11;16(1):87
pubmed: 30205828
Open Vet J. 2021 Apr-Jun;11(2):251-269
pubmed: 34307082
Int J Fertil Steril. 2016 Apr-Jun;10(1):127-35
pubmed: 27123210
Diabetol Metab Syndr. 2017 Dec 01;9:95
pubmed: 29213336
Eur Cytokine Netw. 2017 Nov 1;28(4):141-150
pubmed: 29478964
Theriogenology. 2013 Mar 15;79(5):766-77.e1-3
pubmed: 23312718
Fertil Steril. 2013 Apr;99(5):1256-1263.e3
pubmed: 23375204
Mol Med Rep. 2016 Nov;14(5):4659-4665
pubmed: 27748829
Andrologia. 2021 Feb;53(1):e13617
pubmed: 32399992
Clin Chim Acta. 2013 Apr 18;419:87-94
pubmed: 23422739
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
Fertil Steril. 2010 Oct;94(5):1739-43
pubmed: 20056217
Fertil Steril. 2016 Oct;106(5):1070-1075
pubmed: 27460460
Fertil Steril. 2010 Dec;94(7):2898-901
pubmed: 20667533
Fertil Steril. 2017 Apr;107(4):833-839
pubmed: 28292617
Cell Tissue Bank. 2018 Dec;19(4):653-658
pubmed: 30054759
Adv Biomed Res. 2018 Jul 02;7:107
pubmed: 30069438
Fertil Steril. 2008 Oct;90(4):897-904
pubmed: 18929048
Andrologia. 2020 Mar;52(2):e13485
pubmed: 31815326
Fertil Steril. 2004 Oct;82(4):863-70
pubmed: 15482761
Int J Reprod Biomed. 2017 Oct;15(10):641-648
pubmed: 29387830
Reprod Biomed Online. 2006 Nov;13(5):696-706
pubmed: 17169183
Hum Reprod. 2007 Sep;22(9):2488-93
pubmed: 17636282
J Diabetes Metab Disord. 2014 Dec 23;13(1):121
pubmed: 25610814
J Androl. 2006 May-Jun;27(3):450-2
pubmed: 16339454