Pulmonary Embolism in COVID-19 Patients Is Not Related to a Deterioration of Tissue Oxygenation.
Endotheliitis
Platelet counts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
Systemic inflammation
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
17
12
2022
pubmed:
18
12
2022
medline:
21
12
2022
Statut:
ppublish
Résumé
COVID-19 induces robust systemic inflammation. One of the main complications is the increased coagulation due to endotheliitis. There is an increased incidence of pulmonary embolism (PE) in COVID-19 patients. However, clinical characteristics for a strict analysis are yet to be determined. We evaluated oxygenation and characteristics in patients with COVID-19 PE (CPE). We evaluated 215 COVID-19 patients from 1 January to 30 April 2021. We found 18 patients affected by PE (CPE, 50.0% males, aged 67.00 ± 10.86 years). As controls, we used data from patients affected by PE evaluated in our ward between 1 January 2015 and 31 December 2019 (64 patients, 53.1% males, aged 70.88 ± 16.44 years). All patients underwent a complete physical examination, pulmonary computerised tomography, laboratory tests, D-dimers and blood gas analysis at the time of diagnosis. There were no differences in laboratory tests nor in D-dimers between the two groups. In the CPE group we found a significantly increased pO COVID-19 PE appears to have a different clinical setting. Reduced oxygenation described in PE may not to be considered as a sign of disease. The increased A-aDO
Sections du résumé
BACKGROUND
BACKGROUND
COVID-19 induces robust systemic inflammation. One of the main complications is the increased coagulation due to endotheliitis. There is an increased incidence of pulmonary embolism (PE) in COVID-19 patients. However, clinical characteristics for a strict analysis are yet to be determined.
AIM
OBJECTIVE
We evaluated oxygenation and characteristics in patients with COVID-19 PE (CPE).
MATERIAL AND METHODS
METHODS
We evaluated 215 COVID-19 patients from 1 January to 30 April 2021. We found 18 patients affected by PE (CPE, 50.0% males, aged 67.00 ± 10.86 years). As controls, we used data from patients affected by PE evaluated in our ward between 1 January 2015 and 31 December 2019 (64 patients, 53.1% males, aged 70.88 ± 16.44 years). All patients underwent a complete physical examination, pulmonary computerised tomography, laboratory tests, D-dimers and blood gas analysis at the time of diagnosis.
RESULTS
RESULTS
There were no differences in laboratory tests nor in D-dimers between the two groups. In the CPE group we found a significantly increased pO
DISCUSSION
CONCLUSIONS
COVID-19 PE appears to have a different clinical setting. Reduced oxygenation described in PE may not to be considered as a sign of disease. The increased A-aDO
Identifiants
pubmed: 36527621
doi: 10.1007/978-3-031-14190-4_17
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-103Informations de copyright
© 2022. Springer Nature Switzerland AG.
Références
Cicco S, Cicco G, Racanelli V et al (2020) Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): two potential targets for COVID-19 treatment. Mediat Inflamm 2020:1–25. https://doi.org/10.1155/2020/7527953
doi: 10.1155/2020/7527953
Cicco S, Vacca A, Cariddi C et al (2021) Imaging evaluation of pulmonary and non-ischaemic cardiovascular manifestations of COVID-19. Diagnostics 11:1271. https://doi.org/10.3390/diagnostics11071271
doi: 10.3390/diagnostics11071271
pubmed: 34359355
pmcid: 8304239
Mozzini C, Cicco S, Setti A et al (2021) Spotlight on cardiovascular scoring systems in Covid-19: severity correlations in real-world setting. Curr Probl Cardiol 46:100819. https://doi.org/10.1016/j.cpcardiol.2021.100819
doi: 10.1016/j.cpcardiol.2021.100819
pubmed: 33631706
pmcid: 7883723
Cicco S, Vacca A, Cittadini A et al (2020) Long-term follow-up may be useful in coronavirus disease 2019 survivors to prevent chronic complications. Infect Chemother 52:407. https://doi.org/10.3947/ic.2020.52.3.407
doi: 10.3947/ic.2020.52.3.407
pubmed: 32757498
pmcid: 7533203
Mozzini C, Girelli D (2020) The role of neutrophil extracellular traps in Covid-19: only an hypothesis or a potential new field of research? Thromb Res 191:26–27. https://doi.org/10.1016/j.thromres.2020.04.031
doi: 10.1016/j.thromres.2020.04.031
pubmed: 32360977
pmcid: 7184981
Grillet F, Behr J, Calame P et al (2020) Acute pulmonary embolism associated with COVID-19 pneumonia detected with pulmonary CT angiography. Radiology 296:E186–E188. https://doi.org/10.1148/radiol.2020201544
doi: 10.1148/radiol.2020201544
pubmed: 32324103
Konstantinides SV, Meyer G, Becattini C et al (2019) ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2019:1–61. https://doi.org/10.1093/eurheartj/ehz405
doi: 10.1093/eurheartj/ehz405
Bonaventura A, Vecchié A, Dagna L et al Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol. Published Online First: 6 Apr 2021. https://doi.org/10.1038/s41577-021-00536-9
Miró Ò, Jiménez S et al (2021) Pulmonary embolism in patients with COVID-19: incidence, risk factors, clinical characteristics, and outcome. Eur Heart J 42:3127–3142. https://doi.org/10.1093/eurheartj/ehab314
doi: 10.1093/eurheartj/ehab314
pubmed: 34164664