Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
17 Dec 2022
17 Dec 2022
Historique:
received:
09
04
2021
accepted:
05
12
2022
entrez:
17
12
2022
pubmed:
18
12
2022
medline:
18
12
2022
Statut:
epublish
Résumé
Experimental vaccines for the deadly zoonotic Nipah (NiV), Hendra (HeV), and Ebola (EBOV) viruses have focused on targeting individual viruses, although their geographical and bat reservoir host overlaps warrant creation of multivalent vaccines. Here we explored whether replication-incompetent pseudotyped vesicular stomatitis virus (VSV) virions or NiV-based virus-like particles (VLPs) were suitable multivalent vaccine platforms by co-incorporating multiple surface glycoproteins from NiV, HeV, and EBOV onto these virions. We then enhanced the vaccines' thermotolerance using carbohydrates to enhance applicability in global regions that lack cold-chain infrastructure. Excitingly, in a Syrian hamster model of disease, the VSV multivalent vaccine elicited safe, strong, and protective neutralizing antibody responses against challenge with NiV, HeV, or EBOV. Our study provides proof-of-principle evidence that replication-incompetent multivalent viral particle vaccines are sufficient to provide protection against multiple zoonotic deadly viruses with high pandemic potential.
Identifiants
pubmed: 36528644
doi: 10.1038/s41541-022-00588-5
pii: 10.1038/s41541-022-00588-5
pmc: PMC9759047
doi:
Types de publication
Journal Article
Langues
eng
Pagination
166Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201800013C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109022
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142377
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Methods. 2018 Feb 1;134-135:87-97
pubmed: 29258922
J Virol. 2011 Oct;85(19):9929-44
pubmed: 21775442
Emerg Infect Dis. 2019 Jun;25(6):1144-1152
pubmed: 31107231
J Virol. 2017 Apr 28;91(10):
pubmed: 28250132
Virus Res. 2019 Aug;269:197637
pubmed: 31152757
J Autoimmun. 2020 May;109:102433
pubmed: 32113704
Acta Trop. 2016 Oct;162:114-124
pubmed: 27311387
J Virol. 2007 Oct;81(19):10804-14
pubmed: 17652392
Methods Mol Biol. 2016;1403:295-311
pubmed: 27076138
J Clin Virol. 2003 Apr;26(3):265-75
pubmed: 12637075
Vaccine. 2016 Jun 24;34(30):3525-34
pubmed: 27154393
J Clin Microbiol. 2018 May 25;56(6):
pubmed: 29643201
Environ Dev Sustain. 2021;23(4):5005-5015
pubmed: 32837273
Vaccine. 2000 Nov 22;19(7-8):834-9
pubmed: 11115706
Vaccine. 2018 Aug 28;36(36):5454-5459
pubmed: 28780120
Nat Commun. 2018 Aug 3;9(1):3050
pubmed: 30076303
Vector Borne Zoonotic Dis. 2019 Jul;19(7):455-465
pubmed: 30985268
PLoS One. 2019 Aug 27;14(8):e0221407
pubmed: 31454374
Hum Vaccin Immunother. 2018;14(9):2107-2113
pubmed: 29757706
J Infect Dis. 2019 May 24;219(12):1867-1878
pubmed: 30364984
Annu Rev Pharmacol Toxicol. 2009;49:303-26
pubmed: 18851703
Ther Adv Vaccines. 2015 Sep;3(5-6):125-38
pubmed: 26668751
Antiviral Res. 2013 Oct;100(1):8-13
pubmed: 23838047
J Adv Res. 2020 Mar 16;24:91-98
pubmed: 32257431
Vaccine. 2015 Jun 4;33(24):2823-9
pubmed: 25865472
J Virol Methods. 2010 Feb;163(2):416-23
pubmed: 19903496
Vaccine. 2014 May 19;32(24):2878-81
pubmed: 24631085
Virology. 2002 Apr 25;296(1):190-200
pubmed: 12036330
Expert Rev Vaccines. 2015;14(10):1347-57
pubmed: 26289977
Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3913-3918
pubmed: 29949167
Virus Res. 2005 Oct;113(1):16-25
pubmed: 16139097
Rev Med Virol. 2019 Jan;29(1):e2010
pubmed: 30251294
Virus Res. 1993 Sep;29(3):215-40
pubmed: 8237108
Trends Microbiol. 2003 Sep;11(9):438-44
pubmed: 13678860
Sci Data. 2015 May 26;2:150019
pubmed: 26029377
Aust Vet J. 2018 Apr;96(4):132-141
pubmed: 29399777
Lancet Infect Dis. 2020 Apr;20(4):388-389
pubmed: 31952924
Cell. 2020 Apr 2;181(1):6
pubmed: 32243796
Vet J. 2009 Sep;181(3):211-20
pubmed: 19084436
Vaccine. 2013 Nov 4;31(46):5321-38
pubmed: 24060567
Hum Vaccin Immunother. 2017 Jan 2;13(1):153-168
pubmed: 27764560
Virus Res. 2016 Jan 4;211:174-85
pubmed: 26596227
Nat Commun. 2014 Nov 18;5:5342
pubmed: 25405640
Infect Dis Poverty. 2016 Jul 13;5(1):72
pubmed: 27405359
Brain Pathol. 2015 Sep;25(5):605-13
pubmed: 26276024
Acta Naturae. 2017 Jul-Sep;9(3):4-11
pubmed: 29104771
Virol J. 2013 Jul 16;10:237
pubmed: 23867060
J Immunol. 2010 Nov 1;185(9):5405-16
pubmed: 20870934
Microbes Infect. 2001 Apr;3(4):279-87
pubmed: 11334745
J Virol. 2006 May;80(10):4878-89
pubmed: 16641279
Epidemiol Infect. 2010 Nov;138(11):1630-6
pubmed: 20380769
J Virol. 2016 Jul 11;90(15):6976-6988
pubmed: 27226368