Improving aqueous solubility of paclitaxel with polysarcosine-b-poly(γ-benzyl glutamate) nanoparticles.
NCA polymerization
Nanoparticles
Paclitaxel
Poly(γ-benzyl glutamate)
Polysarcosine
Self-assembly
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Jan 2023
25 Jan 2023
Historique:
received:
30
07
2022
revised:
09
12
2022
accepted:
12
12
2022
pubmed:
19
12
2022
medline:
14
1
2023
entrez:
18
12
2022
Statut:
ppublish
Résumé
New stealth amphiphilic copolymers based on polysarcosine (PSar) rather than poly(ethylene glycol) (PEG) have gained more attention for their use as excipients in nanomedicine. In this study, several polysarcosine-b-poly(γ-benzyl glutamate) (PSar-b-PGluOBn) block copolymers were synthesized by ring opening polymerization (ROP) of the respective N-carboxyanhydrides (NCAs) and were characterized by Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (
Identifiants
pubmed: 36529355
pii: S0378-5173(22)01056-0
doi: 10.1016/j.ijpharm.2022.122501
pii:
doi:
Substances chimiques
polysarcosine
25951-24-0
Paclitaxel
P88XT4IS4D
Glutamic Acid
3KX376GY7L
Excipients
0
Polyethylene Glycols
3WJQ0SDW1A
Polymers
0
Water
059QF0KO0R
Micelles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122501Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.