The cap epitranscriptome: Early directions to a complex life as mRNA.
2′-O-ribose methylation
CMTr
FMRP
Mettl3
YTHDF
capping
m6A
mRNA modifications
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
07
12
2022
received:
13
10
2022
accepted:
08
12
2022
pubmed:
19
12
2022
medline:
25
2
2023
entrez:
18
12
2022
Statut:
ppublish
Résumé
Animal, protist and viral messenger RNAs (mRNAs) are most prominently modified at the beginning by methylation of cap-adjacent nucleotides at the 2'-O-position of the ribose (cOMe) by dedicated cap methyltransferases (CMTrs). If the first nucleotide of an mRNA is an adenosine, PCIF1 can methylate at the N
Identifiants
pubmed: 36529693
doi: 10.1002/bies.202200198
doi:
Substances chimiques
RNA, Messenger
0
Methyltransferases
EC 2.1.1.-
Nucleotides
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200198Subventions
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. BioEssays published by Wiley Periodicals LLC.
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