A novel bis-triazole scaffold accessed via two tandem [3 + 2] cycloaddition events including an uncatalyzed, room temperature azide-alkyne click reaction.
1,2,3-triazoles
intramolecular click reaction
room temperature
uncatalyzed
α-acetyl-α-diazomethane sulfonamide
Journal
Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
09
2022
accepted:
09
11
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
The previously described α-acetyl-α-diazomethanesulfonamide was employed in a three-component reaction with azide-containing benzaldehydes and propargylamines. Besides the initial formation of the triazole core, the reaction proceeded further, in uncatalyzed fashion at room temperature and yielded, after intramolecular azide-alkyne click reaction novel, structurally intriguing bistriazoles.
Identifiants
pubmed: 36530536
doi: 10.3762/bjoc.18.175
pmc: PMC9727270
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1636-1641Informations de copyright
Copyright © 2022, Malkova et al.
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