Acquisition of optical coherence tomography angiography metrics during hemodialysis procedures: A pilot study.
choroidal vessel
circulation
hemodialysis
intradialytic hypotension
optical coherence tomography angiography
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
09
2022
accepted:
03
11
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
The observation of optical microcirculation gives us an extraordinary way to directly assess After the eligibility screening, 15 patients (23 eyes) were included in the study. OCT-A parameters were collected at established time-points: Before treatment (t0), at first hour (t1), at second hour (t2), at third hour (t3), and finally at the end of HD treatment (t4). Patients were finally shared in hypotensive group if they occurred in a hypotensive episode during subsequent month methods or no hypotensive group. The instrument software automatically segmented OCT-A scans into four en-face slabs: The superficial capillary plexus (SCP), the deep capillary plexus (DCP), the outer retinal plexus and the choriocapillaris plexus. In this study we focus on SCP, DCP plexuses. Overall, the majority of ophthalmic parameters remained unaffected and comparable at dialysis end; a significant reduction being observed at the end vs. starting of HD only for deep capillary plexus (DCP: Whole, fovea, and parafovea) and for central choroid thickness (CCT) ( Main achievement of our study was to measure, for the first time in literature, single parameters at different time-points of a HD session. As a result of this process we did not notice a brusque decreasing or increasing of OCT-A metrics but we can characterize the different effect of HD on the two distinct areas distinguishing ocular vessels: Retinal and choroidal circulation. As interesting sub-analysis, Hypotensive group showed for CCT a decreasing trend with a difference statistically significant respect to the group with no-hypotension maintaining a constant trend. In our opinion, these results suggest the role of autonomic system on vessel control in patients affected by uremia.
Sections du résumé
Background and aims
UNASSIGNED
The observation of optical microcirculation gives us an extraordinary way to directly assess
Methods
UNASSIGNED
After the eligibility screening, 15 patients (23 eyes) were included in the study. OCT-A parameters were collected at established time-points: Before treatment (t0), at first hour (t1), at second hour (t2), at third hour (t3), and finally at the end of HD treatment (t4). Patients were finally shared in hypotensive group if they occurred in a hypotensive episode during subsequent month methods or no hypotensive group. The instrument software automatically segmented OCT-A scans into four en-face slabs: The superficial capillary plexus (SCP), the deep capillary plexus (DCP), the outer retinal plexus and the choriocapillaris plexus. In this study we focus on SCP, DCP plexuses.
Results
UNASSIGNED
Overall, the majority of ophthalmic parameters remained unaffected and comparable at dialysis end; a significant reduction being observed at the end vs. starting of HD only for deep capillary plexus (DCP: Whole, fovea, and parafovea) and for central choroid thickness (CCT) (
Conclusion
UNASSIGNED
Main achievement of our study was to measure, for the first time in literature, single parameters at different time-points of a HD session. As a result of this process we did not notice a brusque decreasing or increasing of OCT-A metrics but we can characterize the different effect of HD on the two distinct areas distinguishing ocular vessels: Retinal and choroidal circulation. As interesting sub-analysis, Hypotensive group showed for CCT a decreasing trend with a difference statistically significant respect to the group with no-hypotension maintaining a constant trend. In our opinion, these results suggest the role of autonomic system on vessel control in patients affected by uremia.
Identifiants
pubmed: 36530885
doi: 10.3389/fmed.2022.1057165
pmc: PMC9751028
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1057165Informations de copyright
Copyright © 2022 Coppolino, Bolignano, Presta, Ferrari, Lionetti, Borselli, Randazzo, Andreucci, Bonelli, Errante, Campo, Mauro, Tripodi, Rejdak, Toro, Scorcia and Carnevali.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Ophthalmologica. 2012;227(2):90-4
pubmed: 21921588
Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1453-1454
pubmed: 30237217
Int Ophthalmol. 2013 Oct;33(5):533-9
pubmed: 23456509
Sci Rep. 2018 Apr 4;8(1):5615
pubmed: 29618760
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6534-41
pubmed: 26457539
Biomed Opt Express. 2019 Mar 04;10(4):1532-1544
pubmed: 31061756
Front Physiol. 2019 Jul 05;10:831
pubmed: 31333489
Nat Rev Cardiol. 2019 Jul;16(7):379-381
pubmed: 31089264
J Clin Med. 2020 Feb 21;9(2):
pubmed: 32098215
Sci Rep. 2021 Mar 30;11(1):7202
pubmed: 33785805
Indian J Ophthalmol. 2018 Dec;66(12):1785-1789
pubmed: 30451178
Clin Exp Optom. 2018 Sep;101(5):674-679
pubmed: 29359351
Sci Rep. 2018 Nov 21;8(1):17184
pubmed: 30464196
Am J Ophthalmol. 2020 Sep;217:104-113
pubmed: 32360342
Hemodial Int. 2014 Apr;18(2):415-22
pubmed: 24467830
Br J Ophthalmol. 2014 Feb;98(2):207-12
pubmed: 24187052
Ther Apher Dial. 2007 Oct;11(5):375-81
pubmed: 17845397