Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy.
DNA repair genes
biomarkers
methylome
ovarian carcinoma
resistance
transcriptome
treatment response
whole exome sequencing
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
08
2022
accepted:
14
11
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced stages and frequent therapy resistance. Previous findings suggested that the DNA repair system is involved in the therapeutic response of cancer patients and DNA repair genes are promising targets for novel therapies. This study aimed to address complex inter-relations among gene expression levels, methylation profiles, and somatic mutations in DNA repair genes and EOC prognosis and therapy resistance status. We found significant associations of
Identifiants
pubmed: 36531044
doi: 10.3389/fonc.2022.1016958
pmc: PMC9755737
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1016958Informations de copyright
Copyright © 2022 Seborova, Hlavac, Holy, Bjørklund, Fleischer, Rob, Hruda, Bouda, Mrhalova, Allah, Vodicka, Fiala, Soucek, Kristensen, Vodickova and Vaclavikova.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Immunogenet. 2020 Oct;47(5):443-453
pubmed: 32173978
Medicines (Basel). 2018 Feb 01;5(1):
pubmed: 29389895
Genome Res. 2018 Nov;28(11):1747-1756
pubmed: 30341162
Clin Cancer Res. 2014 Feb 1;20(3):764-75
pubmed: 24240112
Bioinformatics. 2018 Sep 1;34(17):i884-i890
pubmed: 30423086
Oncotarget. 2016 Apr 26;7(17):23156-69
pubmed: 26735576
Transl Oncol. 2021 Jan;14(1):100901
pubmed: 33091827
Clin Epigenetics. 2019 Oct 30;11(1):153
pubmed: 31666131
Cancers (Basel). 2018 Dec 04;10(12):
pubmed: 30518089
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Genome Biol. 2014;15(8):435
pubmed: 25146004
Front Genet. 2019 Sep 12;10:839
pubmed: 31572446
Science. 2001 Feb 16;291(5507):1284-9
pubmed: 11181991
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Nature. 2011 Jun 29;474(7353):609-15
pubmed: 21720365
J Ovarian Res. 2013 Sep 17;6(1):66
pubmed: 24044516
JAMA. 2012 Jan 25;307(4):382-90
pubmed: 22274685
Mol Cell. 2001 Feb;7(2):263-72
pubmed: 11239455
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Int J Mol Sci. 2016 Dec 15;17(12):
pubmed: 27983698
Nat Biotechnol. 2016 May;34(5):525-7
pubmed: 27043002
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
Bioinformatics. 2016 Jan 15;32(2):292-4
pubmed: 26428292
JCO Precis Oncol. 2018;2018:
pubmed: 30234181
Nat Rev Cancer. 2016 Sep;16(9):599-612
pubmed: 27515922
Mol Cancer Res. 2009 Apr;7(4):581-91
pubmed: 19372586
Nat Rev Dis Primers. 2016 Aug 25;2:16061
pubmed: 27558151
Biosci Rep. 2018 Jun 21;38(3):
pubmed: 29669843
Drugs. 2017 Feb;77(2):113-130
pubmed: 28078645
Cell. 2021 Jan 21;184(2):306-322
pubmed: 33450206
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Gynecol Oncol. 2016 Apr;141(1):57-64
pubmed: 27016230
Gigascience. 2021 Feb 16;10(2):
pubmed: 33590861
PLoS One. 2016 Feb 17;11(2):e0149183
pubmed: 26886260
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
Chem Res Toxicol. 2017 Nov 20;30(11):1936-1941
pubmed: 28841305
Curr Opin Pharmacol. 2006 Aug;6(4):337-44
pubmed: 16777480
Hum Mol Genet. 2009 May 15;18(10):1869-78
pubmed: 19270026
JAMA. 2011 Oct 12;306(14):1557-65
pubmed: 21990299
Front Oncol. 2022 Oct 17;12:959407
pubmed: 36324569
Int J Cancer. 2019 Apr 15;144(8):1941-1953
pubmed: 30350310
J Exp Clin Cancer Res. 2012 Feb 13;31:14
pubmed: 22330607
J Clin Oncol. 2015 Sep 10;33(26):2901-7
pubmed: 26261251
Cancer. 2012 Feb 1;118(3):689-97
pubmed: 21751198
Int J Mol Sci. 2021 Feb 27;22(5):
pubmed: 33673424
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
Fam Cancer. 2016 Jul;15(3):359-66
pubmed: 26873719
BMC Bioinformatics. 2010 Nov 30;11:587
pubmed: 21118553
Int J Cancer. 2013 Jun 15;132(12):2778-86
pubmed: 23225521
Oncol Rep. 2017 Jun;37(6):3536-3542
pubmed: 28498431
Pharmacol Ther. 2020 Feb;206:107447
pubmed: 31756363
Gynecol Oncol. 2017 Feb;144(2):396-404
pubmed: 27919574
Anticancer Res. 2007 May-Jun;27(3B):1449-52
pubmed: 17595760
Nat Rev Cancer. 2003 May;3(5):330-8
pubmed: 12724731
Int J Cancer. 2011 Apr 15;128(8):1935-45
pubmed: 20560137
Clin Cancer Res. 2021 Jul 1;27(13):3734-3743
pubmed: 33947694
Cancers (Basel). 2020 Jun 28;12(7):
pubmed: 32605254
Mol Biomed. 2020 Dec 30;1(1):19
pubmed: 35006434
Nat Methods. 2018 Jul;15(7):475-476
pubmed: 29967506
Int J Mol Sci. 2019 Feb 22;20(4):
pubmed: 30813239
Biochem Biophys Res Commun. 2021 Sep 17;570:74-81
pubmed: 34273621
Arch Gynecol Obstet. 2018 Jan;297(1):153-159
pubmed: 29063235
Int J Cancer. 2018 Oct 15;143(8):1935-1942
pubmed: 29726012
Ann Oncol. 2016 Apr;27 Suppl 1:i63-i65
pubmed: 27141075
J Cell Mol Med. 2019 Apr;23(4):2303-2313
pubmed: 30672100
Oncotarget. 2016 Nov 8;7(45):72654-72661
pubmed: 27655643
Semin Cell Dev Biol. 2021 May;113:47-56
pubmed: 32950401
ESMO Open. 2020 Nov;5(6):e001110
pubmed: 33310779
J Clin Oncol. 2020 Oct 20;38(30):3468-3493
pubmed: 32790492
Mol Genet Genomic Med. 2018 Jan;6(1):69-76
pubmed: 29195029
BMC Cancer. 2017 Jan 10;17(1):44
pubmed: 28073364
Cancer Chemother Pharmacol. 2018 Jan;81(1):17-38
pubmed: 29249039
Bioinformatics. 2017 Feb 15;33(4):558-560
pubmed: 28035024
Nat Methods. 2015 Feb;12(2):115-21
pubmed: 25633503
BBA Clin. 2014 Aug 14;2:10-7
pubmed: 26674120
Pharmacogenomics. 2019 Nov;20(17):1225-1233
pubmed: 31691643
Oncol Rep. 2016 Mar;35(3):1349-55
pubmed: 26676960
Clin Epigenetics. 2018 Feb 6;10:15
pubmed: 29445424
Neoplasia. 2011 Nov;13(11):1069-80
pubmed: 22131882
Nucleic Acids Res. 2013 Jan 7;41(1):229-41
pubmed: 23118481
Oncogene. 2016 May 5;35(18):2279-86
pubmed: 26364595
Genome Biol. 2012 Jun 15;13(6):R44
pubmed: 22703947
J Med Genet. 2003 Dec;40(12):e131
pubmed: 14684699
Epigenomics. 2012 Jun;4(3):325-41
pubmed: 22690668
Gynecol Oncol. 2018 Jul;150(1):92-98
pubmed: 29716739