Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause.
Ageing
blood vessels
oestrogen
postmenopausal bone loss
sex differences
Journal
Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
ppublish
Résumé
The mammalian skeletal system shows sex differences in structure, functions, ageing and disease incidences. The role of blood vessels in physiological, regenerative and pathological bone functions indicates the requisite to understanding their sex specificity. Here, we find oestrogen regulates blood vessel physiology during pregnancy and menopause through oestrogen receptor alpha (ERα) and G-protein coupled oestrogen receptor-1 (Gper1) but not ERβ-dependent signalling in mice. Oestrogen regulates BECs' lipid use and promotes lipolysis of adipocytes and FA uptake from the microenvironment. Low oestrogen conditions skew endothelial FA metabolism to accumulate lipid peroxides (LPO), leading to vascular ageing. High ferrous ion levels in female BECs intensify LPO accumulation and accelerate the ageing process. Importantly, inhibiting LPO generation using liproxstatin-1 in aged mice significantly improved bone heath. Thus, our findings illustrate oestrogen's effects on BECs and suggest LPO targeting could be an efficient strategy to manage blood and bone health in females.
Types de publication
Journal Article
Langues
eng
Pagination
918-932Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202300
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1605/1
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing Interests Statement The authors declare no competing financial interests
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