The serotonin receptor 5-HT2A modulates lifespan and protein feeding in
Drosophila melanogaster
genetics
lifespan
nutrients
protein
serotonin
Journal
Frontiers in aging
ISSN: 2673-6217
Titre abrégé: Front Aging
Pays: Switzerland
ID NLM: 9918231199706676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
10
2022
accepted:
14
11
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
The conserved neurotransmitter serotonin has been shown to be an important modulator of lifespan in specific nutritional contexts; however, it remained unclear how serotonin signaling influences lifespan under normal conditions. Here, we show that serotonin signaling through the 5-HT2A receptor influences lifespan, behavior, and physiology in
Identifiants
pubmed: 36531741
doi: 10.3389/fragi.2022.1068455
pii: 1068455
pmc: PMC9751412
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1068455Subventions
Organisme : NIA NIH HHS
ID : T32 AG000114
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063371
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG030593
Pays : United States
Organisme : NIA NIH HHS
ID : R61 AG078428
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG051649
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG051649
Pays : United States
Informations de copyright
Copyright © 2022 Munneke, Chakraborty, Porter, Gendron and Pletcher.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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