Online Hemodiafiltration Compared to Conventional Hemodialysis in Critically Ill Patients.
acute kidney injury
convective clearance
hemodiafiltration
hemodialysis
inflammation
renal replacement therapy
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
29
04
2022
revised:
15
08
2022
accepted:
15
08
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
Online hemodiafiltration (HDF) has been increasingly used for improved clearance of middle molecular weight toxins. The impact of this mode of clearance is unknown in critically ill patients. We aimed to determine whether the use of HDF in acute kidney injury (AKI) is associated with lower mortality and improved kidney recovery up to 90 days after initiation of therapy. Single-center retrospective cohort study using data from 2017 to 2020 of adults with AKI who initiated intermittent renal replacement therapy (IRRT) in the intensive care unit (ICU), using either hemodialysis (HD) or HDF depending on the maintenance status of the water system without regards for patient characteristics. We assessed association with patient-events and session-events using time-dependent Cox models and general estimating equations models, respectively. We included 182 adults with AKI for whom 848 IRRT sessions were performed in the ICU. The 90-day mortality rate was 43 of 182 (24.6%). There was no significant association with the use of HDF and mortality (adjusted hazard ratio [aHR]: 0.85 (0.43; 1.67) The use of HDF in the setting of AKI was not associated with a differential risk of mortality or kidney recovery.
Identifiants
pubmed: 36531895
doi: 10.1016/j.ekir.2022.08.007
pii: S2468-0249(22)01706-5
pmc: PMC9751768
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2376-2387Informations de copyright
© 2022 International Society of Nephrology. Published by Elsevier Inc.
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