Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder.
ADHD
BrainAGE
brain
development
machine learning
relevance vector
sex
siblings
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
08
2022
accepted:
14
11
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
Attention-deficit hyperactivity disorder (ADHD) is a debilitating disorder with apparent roots in abnormal brain development. Here, we quantified the level of individual brain maturation in children with ADHD using structural neuroimaging and a recently developed machine learning algorithm. More specifically, we compared the BrainAGE index between three groups matched for chronological age (mean ± SD: 11.86 ± 3.25 years): 89 children diagnosed with ADHD, 34 asymptomatic siblings of those children with ADHD, and 21 unrelated healthy control children. Brains of children with ADHD were estimated significantly younger (-0.85 years) than brains of healthy controls (Cohen's
Identifiants
pubmed: 36532197
doi: 10.3389/fpsyt.2022.1019546
pmc: PMC9755736
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1019546Informations de copyright
Copyright © 2022 Kurth, Levitt, Gaser, Alger, Loo, Narr, O’Neill and Luders.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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