Maternal adverse childhood experiences and infant subcortical brain volume.
Amygdala
Gray matter volume
Hippocampus
Intergenerational transmission
Maternal adverse childhood experiences
Negative emotionality
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
05
04
2022
revised:
19
08
2022
accepted:
13
09
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
20
12
2022
Statut:
epublish
Résumé
A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age. The sample included 85 mother-infant dyads (44 female infants) from a longitudinal study. Maternal ACEs were assessed with the Adverse Childhood Experiences Questionnaire (ACE-Q) and neonatal hippocampal and amygdala volume was assessed using structural magnetic resonance imaging (MRI). Infant negative emotionality was assessed at 6 months using the Infant Behavior Questionnaire (IBQ). Multivariate analyses demonstrated that maternal ACEs were associated with bilateral amygdala volume ( Maternal ACEs are associated with both newborn amygdala volume and subsequent infant negative emotionality. These findings linking maternal adverse childhood experiences and infant brain development and temperament provide evidence to support the intergenerational transmission of adversity from mother to child.
Sections du résumé
Background
UNASSIGNED
A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age.
Methods
UNASSIGNED
The sample included 85 mother-infant dyads (44 female infants) from a longitudinal study. Maternal ACEs were assessed with the Adverse Childhood Experiences Questionnaire (ACE-Q) and neonatal hippocampal and amygdala volume was assessed using structural magnetic resonance imaging (MRI). Infant negative emotionality was assessed at 6 months using the Infant Behavior Questionnaire (IBQ).
Results
UNASSIGNED
Multivariate analyses demonstrated that maternal ACEs were associated with bilateral amygdala volume (
Conclusions
UNASSIGNED
Maternal ACEs are associated with both newborn amygdala volume and subsequent infant negative emotionality. These findings linking maternal adverse childhood experiences and infant brain development and temperament provide evidence to support the intergenerational transmission of adversity from mother to child.
Identifiants
pubmed: 36532374
doi: 10.1016/j.ynstr.2022.100487
pii: S2352-2895(22)00062-5
pmc: PMC9755027
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100487Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
Dr. Bagonis reports employment at PrimeNeuro. All other authors report having no biomedical financial interests or potential conflicts of interest.
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