Paediatric-type diffuse low-grade gliomas: a clinically and biologically distinct group of tumours with a favourable outcome.

angiocentric glioma diffuse astrocytoma altered by MYB or MYBL1 diffuse low-grade glioma with an altered MAPK pathway low-grade polymorphic juvenile neuroepithelial tumour paediatric-type diffuse low grade glioma

Journal

Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 03 11 2022
accepted: 12 11 2022
entrez: 19 12 2022
pubmed: 20 12 2022
medline: 22 12 2022
Statut: ppublish

Résumé

The WHO 2021 classification of central nervous system cancers distinguishes diffuse gliomas that arise in adults (referred to as the "adult type") and those that arise in children (defined as "paediatric") based on clinical and molecular characteristics."). However, paediatric-type gliomas may occasionally be present in younger adults and occasionally adult-type gliomas may occur in children. Diffuse low-grade paediatric glioma includes diffuse astrocytoma altered by MYB or MYBL1, low-grade polymorphic juvenile neuroepithelial tumour, angiocentric glioma, and diffuse low-grade glioma with an altered MAPK pathway. Here, we examine these newly recognised entities according to WHO diagnostic criteria and propose an integrated diagnostic approach that can be used to separate these clinically and biologically distinct tumor groups.

Identifiants

pubmed: 36534420
doi: 10.32074/1591-951X-828
pmc: PMC9763978
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

410-421

Informations de copyright

Copyright © 2022 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.

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Auteurs

Viscardo Paolo Fabbri (VP)

Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, Italy.
Azienda Ospedaliero Universitaria Policlinico Modena, Modena, Italy.

Chiara Caporalini (C)

Pathology Unit, Meyer Children's Hospital, Firenze, Italy.

Sofia Asioli (S)

Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, Italy.
Programma Neurochirurgia Ipofisi- Pituitary Unit, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Annamaria Buccoliero (A)

Pathology Unit, Meyer Children's Hospital, Firenze, Italy.

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Classifications MeSH