Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.
DMG with EZHIP overexpression
ETV6-NTRK3
MEF2D-NTRK1
MYC amplification
MYCN amplification
PDGFRA amplification
RTK fusions
ZCCHC8-ROS1
diffuse hemispheric glioma H3 G34-mutant
diffuse midline glioma K27M-altered
diffuse paediatric-type high grade glioma H3-wildtype and IDH-wildtype
infant-type hemispheric glioma
infant-type hemispheric glioma with atypical location
pHGG MYCN
pHGG RTK1
pHGG RTK2
paediatric high-grade glioma
radiation-induced gliomas
Journal
Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
12
11
2022
accepted:
12
11
2022
entrez:
19
12
2022
pubmed:
20
12
2022
medline:
22
12
2022
Statut:
ppublish
Résumé
As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive pathobiology underlying gliomas arising primarily in children by recognizing for the first time the families of paediatric-type diffuse gliomas, both high-grade and low-grade. This review will focus on the family of paediatric-type diffuse high-grade gliomas, which includes four tumour types: 1) Diffuse midline glioma H3 K27-altered; 2) Diffuse hemispheric glioma H3 G34-mutant; 3) Diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype; and 4) Infant-type hemispheric glioma. The essential and desirable diagnostic criteria as well as the entities entering in the differential will be discussed for each tumour type. A special focus will be given on the issues encountered in the daily practice, especially regarding the diagnosis of the diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype. The advantages and the limits of the multiple molecular tests which may be utilised to define the entities of this tumour family will be evaluated in each diagnostic context.
Identifiants
pubmed: 36534421
doi: 10.32074/1591-951X-830
pmc: PMC9763979
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
422-435Informations de copyright
Copyright © 2022 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
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