Characterization of the Novel P2X7 Receptor Radioligand [
P2X7
TSPO
autoradiography
epilepsy
neuroinflammation
purinergic receptor
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
04 01 2023
04 01 2023
Historique:
pubmed:
20
12
2022
medline:
6
1
2023
entrez:
19
12
2022
Statut:
ppublish
Résumé
Radioligands targeting microglia cells have been developed to identify and determine neuroinflammation in the living brain. One recently discovered ligand is JNJ-64413739 that binds selectively to the purinergic receptor P2X7R. The expression of P2X7R is increased under inflammation; hence, the ligand is considered useful in the detection of neuroinflammation in the brain. [
Identifiants
pubmed: 36535632
doi: 10.1021/acschemneuro.2c00561
pmc: PMC9817075
doi:
Substances chimiques
Iodine-123
8YWR746RPQ
Ligands
0
Receptors, GABA
0
Receptors, Purinergic P2X7
0
TSPO protein, human
0
Peptides
0
Radiopharmaceuticals
0
Tritium
10028-17-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111-118Références
J Nucl Med. 2019 Aug;60(8):1154-1159
pubmed: 30733317
Sci Rep. 2021 Aug 9;11(1):16172
pubmed: 34373571
J Neurosci. 2012 Aug 22;32(34):11559-73
pubmed: 22915101
Neurochem Int. 2008 May;52(6):1148-59
pubmed: 18242779
Epilepsia. 2013 Sep;54(9):1551-61
pubmed: 23808395
J Nucl Med. 2019 Jul;60(7):930-936
pubmed: 30655332
J Neurosci. 2017 Jul 26;37(30):7063-7072
pubmed: 28747389
Neurosci Bull. 2020 Nov;36(11):1242-1258
pubmed: 32895896
Front Mol Neurosci. 2021 Apr 27;14:656011
pubmed: 33986644
Neurochem Int. 2020 Sep;138:104773
pubmed: 32531197
Mol Imaging Biol. 2019 Oct;21(5):871-878
pubmed: 30632003
Biochem Biophys Res Commun. 2005 Jun 24;332(1):17-27
pubmed: 15896293
J Biol Chem. 1997 Feb 28;272(9):5482-6
pubmed: 9038151
Epilepsia. 2016 Jan;57(1):99-110
pubmed: 26714441
EJNMMI Res. 2017 Dec;7(1):31
pubmed: 28374288
J Neurosci. 2017 Jul 26;37(30):7049-7062
pubmed: 28747388
J Neurosci. 2007 Aug 29;27(35):9525-33
pubmed: 17728465
Front Cell Neurosci. 2019 Apr 12;13:143
pubmed: 31031598
Lancet Neurol. 2020 Nov;19(11):940-950
pubmed: 33098803
Prog Neurobiol. 2021 Sep;204:102105
pubmed: 34144123
J Immunol. 2006 Apr 1;176(7):3877-83
pubmed: 16547218
Front Cell Neurosci. 2022 Jul 07;16:910662
pubmed: 35875355
Front Neurosci. 2017 Feb 02;11:21
pubmed: 28210205
Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2051-2064
pubmed: 31243495
Glia. 2008 May;56(7):734-49
pubmed: 18293404
J Med Chem. 2021 Apr 22;64(8):4891-4902
pubmed: 33822617
J Nucl Med. 2016 Sep;57(9):1436-41
pubmed: 27199364
Glia. 2016 Oct;64(10):1772-87
pubmed: 27219534
Epilepsia. 2012 Nov;53(11):1978-86
pubmed: 23106524
Front Mol Neurosci. 2020 Jul 31;13:124
pubmed: 32848594
Glia. 2014 Nov;62(11):1762-79
pubmed: 24753049
Cell. 2019 Oct 17;179(3):659-670.e13
pubmed: 31587896
Brain Res. 2008 Feb 15;1194:45-55
pubmed: 18177631
Neuropharmacology. 2016 May;104:140-53
pubmed: 26549853
Trends Pharmacol Sci. 2014 Oct;35(10):537-47
pubmed: 25223574
Int J Mol Sci. 2022 Feb 21;23(4):
pubmed: 35216493
Front Cell Neurosci. 2019 Dec 05;13:538
pubmed: 31866830
Neuromolecular Med. 2016 Jun;18(2):158-69
pubmed: 26969181
J Neuroinflammation. 2017 Jul 17;14(1):135
pubmed: 28716092
J Nucl Med. 2020 Apr;61(4):604-607
pubmed: 31562223
Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):379-389
pubmed: 31705174
Eur J Nucl Med Mol Imaging. 2021 Dec;49(1):164-173
pubmed: 33735406
J Immunol. 2009 Apr 1;182(7):4378-85
pubmed: 19299738
J Nucl Med. 2017 Mar;58(3):458-465
pubmed: 27765863
J Neurosci Res. 2016 Sep;94(9):781-93
pubmed: 27302739
FASEB J. 2012 Apr;26(4):1616-28
pubmed: 22198387
Mol Brain. 2022 May 16;15(1):45
pubmed: 35578248
Epilepsy Res. 2009 Feb;83(2-3):157-67
pubmed: 19084381
J Nucl Med. 2019 May;60(5):683-690
pubmed: 30262518