Cardiovascular predictors of mortality and exacerbations in patients with COPD.

Humans Coronary Artery Disease Lung Pulmonary Disease, Chronic Obstructive Comorbidity Forced Expiratory Volume Hypertension Disease Progression

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 12 2022
Historique:
received: 31 05 2022
accepted: 07 12 2022
entrez: 19 12 2022
pubmed: 20 12 2022
medline: 22 12 2022
Statut: epublish

Résumé

In chronic obstructive pulmonary disease (COPD), comorbidities and worse functional status predict worse outcomes, but how these predictors compare with regard to different outcomes is not well studied. We thus compared the role of cardiovascular comorbidities for mortality and exacerbations. Data from baseline and up to four follow-up visits of the COSYCONET cohort were used. Cox or Poisson regression was employed to determine the relationship of predictors to mortality or mean annual exacerbation rate, respectively. Predictors comprised major comorbidities (including cardiovascular disease), lung function (forced expiratory volume in 1 s [FEV

Identifiants

DOI: 10.1038/s41598-022-25938-0 PMID: 36536050 PMC: PMC9763357
pubmed: 36536050
doi: 10.1038/s41598-022-25938-0
pii: 10.1038/s41598-022-25938-0
pmc: PMC9763357
doi:

Banques de données

ClinicalTrials.gov
['NCT01245933']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

21882

Informations de copyright

© 2022. The Author(s).

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Auteurs

Peter Alter (P)

Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Baldingerstrasse 1, 35033, Marburg, Germany. Alter@uni-marburg.de.

Tanja Lucke (T)

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.

Henrik Watz (H)

Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Pulmonary Research Institute at LungenClinic Grosshansdorf, Grosshansdorf, Germany.

Stefan Andreas (S)

LungClinic Immenhausen and Department of Cardiology and Pneumology, University Medical Center Göttingen, Member of the German Center for Lung Research (DZL), Göttingen, Germany.

Kathrin Kahnert (K)

Department of Internal Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.

Franziska C Trudzinski (FC)

Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.

Tim Speicher (T)

Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Baldingerstrasse 1, 35033, Marburg, Germany.

Sandra Söhler (S)

Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Baldingerstrasse 1, 35033, Marburg, Germany.

Robert Bals (R)

Department of Internal Medicine V - Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany.

Benjamin Waschki (B)

Department of Pneumology, Hospital Itzehoe, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), LungenClinic Grosshansdorf, Grosshansdorf, Germany.
Department of Cardiology, University Heart Center Hamburg, Hamburg, Germany.

Tobias Welte (T)

Clinic for Pneumology, Hannover Medical School, Member of the German Center for Lung Research (DZL), Hannover, Germany.

Klaus F Rabe (KF)

LungenClinic Grosshansdorf and Department of Medicine, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Christian-Albrechts University, Kiel, Kiel/Grosshansdorf, Germany.

Jørgen Vestbo (J)

Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.

Emiel F M Wouters (EFM)

Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.

Claus F Vogelmeier (CF)

Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Baldingerstrasse 1, 35033, Marburg, Germany.

Rudolf A Jörres (RA)

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.

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