Relationship of size of corpus callosum with white matter changes in elderly population; A retrospective analytical cross-sectional study.
CC, Corpus Callosum
Corpus callosum
Correlation
Elderly
MRI, Magnetic Resonance Imaging
Magnetic resonance imaging
WMC, White Matter Changes
WMH, White Matter Hyperintensity
WML, White Matter Lesions
White matter changes
White matter hyperintensity
Journal
Annals of medicine and surgery (2012)
ISSN: 2049-0801
Titre abrégé: Ann Med Surg (Lond)
Pays: England
ID NLM: 101616869
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
05
09
2022
revised:
23
10
2022
accepted:
12
11
2022
entrez:
20
12
2022
pubmed:
21
12
2022
medline:
21
12
2022
Statut:
epublish
Résumé
To study the relationship of size of corpus callosum with white matter changes in the elderly population. This was a retrospective analytical cross-sectional study. The relationship between the corpus callosum and white matter changes was studied using the magnetic resonance imaging technique, where white matter changes were graded based on Fazekas grading. The Spearman rank order correlation was used to assess the relationship between the size of corpus callosum and white matter changes. The whole corpus callosum (ρ = 0.165, p = 0.044) and rostrum (ρ = -0.232, p = 0.004) was significantly correlated with white matter changes based on Fazekas severity grading. Similarly, in bivariate regression analysis, white matter changes were strongly correlated with rostrum (standardized β-coefficient = -0.186, p = 0.023). While taking gender in sub-group analysis, white matter changes were significantly correlated with rostrum (ρ = -0.252, p = 0.021) and splenium (ρ = -0.229, p = 0.036) in male and with rostrum (ρ = -0.245, p = 0.048) only in female groups. Corpus callosum size is associated with white matter changes in the elderly population. This association can give insight into the neuropathology of diseases involving the central nervous system.
Identifiants
pubmed: 36536725
doi: 10.1016/j.amsu.2022.104953
pii: S2049-0801(22)01713-7
pmc: PMC9758332
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104953Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
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