Biological variation: recent development and future challenges.
BIVAC
EuBIVAS
biological variation
personalized reference intervals (prRI)
reference change value
Journal
Clinical chemistry and laboratory medicine
ISSN: 1437-4331
Titre abrégé: Clin Chem Lab Med
Pays: Germany
ID NLM: 9806306
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
10
12
2022
accepted:
12
12
2022
medline:
3
4
2023
pubmed:
21
12
2022
entrez:
20
12
2022
Statut:
epublish
Résumé
Biological variation (BV) data have many applications in laboratory medicine. However, these depend on the availability of relevant and robust BV data fit for purpose. BV data can be obtained through different study designs, both by experimental studies and studies utilizing previously analysed routine results derived from laboratory databases. The different BV applications include using BV data for setting analytical performance specifications, to calculate reference change values, to define the index of individuality and to establish personalized reference intervals. In this review, major achievements in the area of BV from last decade will be presented and discussed. These range from new models and approaches to derive BV data, the delivery of high-quality BV data by the highly powered European Biological Variation Study (EuBIVAS), the Biological Variation Data Critical Appraisal Checklist (BIVAC) and other standards for deriving and reporting BV data, the EFLM Biological Variation Database and new applications of BV data including personalized reference intervals and measurement uncertainty.
Identifiants
pubmed: 36537071
pii: cclm-2022-1255
doi: 10.1515/cclm-2022-1255
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
741-750Informations de copyright
© 2022 Walter de Gruyter GmbH, Berlin/Boston.
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